Date published: 2026-5-15

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NET-7 Inhibitors

NET-7 inhibitors represent a category of chemical agents specifically designed to suppress the activity of NET-7, a fictional enzyme involved in critical cellular processes. These inhibitors are developed with the intention of directly interacting with the NET-7 protein, leading to a decrease in its enzymatic activity. By targeting NET-7, these chemicals can influence the cellular pathways and processes regulated by this enzyme, potentially affecting the overall cellular homeostasis and function. The inhibition of NET-7 involves the binding of these chemicals to the active site or allosteric sites of the enzyme, thereby blocking its interaction with substrates or cofactors essential for its activity. This blockade can result in the modulation of the cellular signaling pathways and biological processes in which NET-7 plays a pivotal role. The development of NET-7 inhibitors is guided by a deep understanding of the enzyme's structure, the biochemical pathways it influences, and the role it plays in cellular physiology.

The research and development process for NET-7 inhibitors encompasses a series of methodological approaches, including computational modeling to predict the interaction between potential inhibitors and the NET-7 protein, biochemical assays to confirm these interactions and measure their impact on enzyme activity, and cellular assays to observe the downstream effects on cellular functions. Techniques such as molecular docking and dynamic simulation are employed to identify molecules with high binding affinity for NET-7, while kinetic studies provide insights into how these interactions affect the enzyme's function. Further, the use of cell-based assays helps in understanding the physiological relevance of NET-7 inhibition, including changes in cellular signaling pathways, alterations in gene expression, and impacts on cell proliferation, differentiation, or apoptosis. Through these comprehensive research strategies, scientists aim to elucidate the mechanisms by which NET-7 inhibitors exert their effects, providing valuable insights into the role of NET-7 in cellular processes and the potential for modulating its activity for investigative purposes.

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Items 1 to 10 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

GW 280264X

866924-39-2sc-507540
5 mg
$720.00
(0)

GW280264X inhibits ADAM10, a protease regulated by NET-7, thereby disrupting NET-7's ability to facilitate ADAM10's maturation and trafficking.

GI 254023X

260264-93-5sc-490114
1 mg
$166.00
1
(0)

GI 254023X targets ADAM10 and interrupts NET-7's regulatory role in CDH2 cleavage and Notch signaling by impeding ADAM10 activity.

Marimastat

154039-60-8sc-202223
sc-202223A
sc-202223B
sc-202223C
sc-202223E
5 mg
10 mg
25 mg
50 mg
400 mg
$168.00
$218.00
$404.00
$629.00
$4900.00
19
(1)

Marimastat inhibits metalloproteases, including ADAM10, thereby affecting NET-7's function in the maturation and trafficking of ADAM10.

TAPI-1

171235-71-5sc-222337
1 mg
$669.00
15
(1)

TAPI-1 directly inhibits the activity of ADAM10, which is regulated by NET-7, thus impacting NET-7’s ability to regulate CDH2 cleavage.

Batimastat

130370-60-4sc-203833
sc-203833A
1 mg
10 mg
$179.00
$377.00
24
(1)

Batimastat acts as an ADAM10 inhibitor and disrupts NET-7's role in ADAM10 maturation and trafficking.

DAPT

208255-80-5sc-201315
sc-201315A
sc-201315B
sc-201315C
5 mg
25 mg
100 mg
1 g
$40.00
$120.00
$480.00
$2141.00
47
(3)

DAPT inhibits gamma-secretase and can reduce Notch signaling, which NET-7 negatively regulates, thus affecting NET-7's role in Notch pathway regulation.

LY411575

209984-57-6sc-364529
sc-364529A
10 mg
50 mg
$198.00
$473.00
6
(1)

LY411575 inhibits gamma-secretase, reducing Notch signaling, and in doing so, indirectly affects NET-7's role in regulating this pathway.

RO-4929097

847925-91-1sc-364602
sc-364602A
10 mg
50 mg
$439.00
$1417.00
1
(1)

RO-4929097 acts as a gamma-secretase inhibitor, affecting Notch signaling and, by extension, NET-7's regulatory role in this pathway.

Dibenzazepine (Deshydroxy LY 411575)

209984-56-5sc-207554
sc-207554A
2 mg
5 mg
$235.00
$260.00
4
(1)

Dibenzazepine (Deshydroxy LY 411575) is a gamma-secretase inhibitor that affects Notch signaling, thereby affecting NET-7's ability to regulate this pathway.

L-685,458

292632-98-5sc-204042
sc-204042A
1 mg
5 mg
$337.00
$1000.00
4
(1)

L-685,458 inhibits gamma-secretase, reducing Notch signaling, which is negatively regulated by NET-7.