NEPH3 Activators
NEPH3 activators constitute a class of chemical agents that specifically enhance the activity of the NEPH3 (nephrin-like 3) protein. NEPH3, also known as KIRREL2, is a member of the nephrin-like protein family, which plays an important role in the development and function of the kidney's filtration system. This family of proteins is primarily involved in cell-cell adhesion processes and the maintenance of structures known as slit diaphragms, which are critical components of the glomerular filter in the kidneys. The activation of NEPH3 is of interest in the biochemical context for its role in these cell adhesion processes, and because it influences the molecular composition and function of the slit diaphragms.
Chemical activators of NEPH3 typically function by increasing the protein's natural activity or by stabilizing its expression and presence at the cell surface. These activators can act by various mechanisms, such as binding directly to NEPH3 and stabilizing its active conformation, enhancing the protein's expression through upregulation of its gene transcription, or by modulating the activity of other proteins that interact with NEPH3, thereby indirectly increasing its functional activity. The precise action of these activators often depends on a thorough understanding of NEPH3's structure, the regulatory elements of its gene, and the complex network of interactions in which it is involved within the cell.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid may upregulate the expression of NEPH3 by promoting neuronal development and differentiation, processes in which NEPH3 is known to participate. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
As a DNA methyltransferase inhibitor, 5-Azacytidine could potentially stimulate NEPH3 expression by demethylating its promoter region. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A, a histone deacetylase inhibitor, might enhance NEPH3 transcription by increasing the acetylation of histones associated with the NEPH3 gene. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin could potentially boost NEPH3 expression by raising intracellular cAMP levels, leading to the activation of cAMP response element-binding proteins that may target NEPH3. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate, by inhibiting histone deacetylases, may drive NEPH3 expression by causing a hyperacetylation of histones in the NEPH3 gene region, facilitating its transcription. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone might propel NEPH3 expression by activating glucocorticoid responsive elements in the promoter region of the NEPH3 gene. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $120.00 $326.00 $634.00 $947.00 $1259.00 | 38 | |
Rosiglitazone could potentially promote NEPH3 expression by triggering peroxisome proliferator-activated receptor gamma (PPARγ) which might bind to PPAR response elements in the promoter of the NEPH3 gene. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin may augment NEPH3 expression by modulating the activity of transcription factors such as NF-kB, which could possibly bind to the promoter region of NEPH3. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride may increase NEPH3 expression by inhibiting GSK-3β, leading to the accumulation of β-catenin, which could bind to TCF/LEF transcription factors that regulate NEPH3. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
By activating SIRT1, resveratrol may amplify NEPH3 expression as SIRT1 has been shown to regulate the expression of several genes. | ||||||