Nek8 Activators
Nek8 activators primarily interface with the intricate DNA damage response pathway. Agents like Cisplatin, Etoposide, Doxorubicin, and Camptothecin all act as DNA damaging agents, thereby inducing a cascade of cellular responses in which Nek8 becomes consequential. Specifically, DNA damaging agents like Cisplatin induce changes at the molecular level, catalyzing responses where Nek8 is vital for cell cycle checkpoint maintenance.
Another dimension of Nek8 activation arises from replication stress inducers such as Hydroxyurea, Aphidicolin, and Mimosine. These chemicals challenge DNA replication, thereby setting off a chain of responses where Nek8 serves as a sentinel. On the other hand, Forskolin and IBMX delineate the influence of cyclic AMP modulation on cellular processes, potentially bringing Nek8 into play, especially in contexts like cilia-associated signaling.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
A DNA damaging agent, which can induce DNA damage response where Nek8 plays a role. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
Induces replication stress, which can influence the DNA damage response pathway and subsequently, Nek8 activity. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
A topoisomerase II inhibitor that causes DNA double-strand breaks, potentially activating Nek8. | ||||||
Aphidicolin | 38966-21-1 | sc-201535 sc-201535A sc-201535B | 1 mg 5 mg 25 mg | $84.00 $306.00 $1104.00 | 30 | |
A DNA polymerase inhibitor inducing replication stress, which may influence Nek8 activation. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
An activator of adenylate cyclase, impacting cAMP levels which can affect cellular processes involving Nek8, particularly in cilia-associated signaling. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
A phosphodiesterase inhibitor raising intracellular cAMP levels which can indirectly activate pathways where Nek8 is active. | ||||||
L-Mimosine | 500-44-7 | sc-201536A sc-201536B sc-201536 sc-201536C | 25 mg 100 mg 500 mg 1 g | $36.00 $88.00 $220.00 $436.00 | 8 | |
Induces replication stress, potentially influencing Nek8's role in the DNA damage response. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
An inhibitor of topoisomerase I leading to DNA breaks and potentially activating Nek8 through the DNA damage response. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $176.00 $426.00 | 43 | |
A DNA intercalating agent that induces DNA damage, potentially influencing the DNA damage response and Nek8 activation. | ||||||