NDC1 Activators
NDC1 (Nuclear Division Cycle 1) is a protein that is integral to the nuclear pore complex (NPC), which serves as a pivotal gateway regulating the transport of molecules between the nucleus and the cytoplasm. NDC1 is involved in the assembly and maintenance of the NPC and is crucial for proper cell cycle progression and nucleocytoplasmic transport.
Activators of NDC1 would be chemicals that either directly or indirectly enhance the function of the NDC1 protein. Direct activators would likely interact with NDC1 at specific sites to promote its incorporation into the NPC or to stabilize its structure within the complex. This interaction could enhance the efficiency of NPC assembly or the transport functions of the complex, facilitating a more robust exchange of molecules between the nucleus and the cytoplasm. Indirect activators of NDC1 might function by modulating cellular pathways that influence the expression levels of NDC1 or the post-translational modifications that regulate its activity. For example, they may upregulate the transcription of the NDC1 gene, leading to increased protein synthesis. Alternatively, they could inhibit proteases responsible for NDC1 degradation, thereby extending the protein's functional lifespan within the cell. Indirect activators might also affect the phosphorylation state of NDC1, altering its interaction with other NPC components and affecting its role in NPC assembly and function.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a JNK activator. JNK activation can stimulate the translocation of various nuclear factors, which may influence the expression or activity of NDC1 if it's a target of these factors. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin is an ER stress inducer that triggers the unfolded protein response (UPR). If NDC1 is part of the UPR or is regulated by it, this can potentially enhance its activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor which can indirectly activate the AMPK pathway. If NDC1 is involved in the AMPK pathway or is regulated by it, this can potentially enhance its activity. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
AICAR is an AMP-activated protein kinase (AMPK) activator. If NDC1 is involved in the AMPK pathway or is regulated by it, AICAR can potentially enhance its activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor which can indirectly activate autophagy. If NDC1 is involved in autophagy or is regulated by it, this can potentially enhance its activity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol is a SIRT1 activator. If NDC1 is involved in the SIRT1 pathway or is regulated by it, Resveratrol can potentially enhance its activity. | ||||||
Metformin-d6, Hydrochloride | 1185166-01-1 | sc-218701 sc-218701A sc-218701B | 1 mg 5 mg 10 mg | $286.00 $806.00 $1510.00 | 1 | |
Metformin is an AMPK activator. If NDC1 is involved in the AMPK pathway or is regulated by it, Metformin can potentially enhance its activity. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $169.00 $299.00 | 66 | |
Tunicamycin is an ER stress inducer that triggers the unfolded protein response (UPR). If NDC1 is part of the UPR or is regulated by it, this can potentially enhance its activity. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG132 is a proteasome inhibitor which can indirectly increase the levels of various proteins. If NDC1 is degraded by the proteasome, MG132 can potentially increase its levels and activity. | ||||||
SB202190 hydrochloride | 350228-36-3 | sc-222294 sc-222294A | 1 mg 5 mg | $128.00 $495.00 | 13 | |
SB202190 is a p38 MAPK inhibitor which can indirectly activate the JNK pathway. If NDC1 is involved in the JNK pathway or regulated by it, this can potentially enhance its activity. | ||||||