Date published: 2026-2-10

1-800-457-3801

SCBT Portrait Logo
Seach Input

NCoA-3 Inhibitors

Nuclear Coactivator 3 (NCoA-3), also known as Steroid Receptor Coactivator-3 (SRC-3), is a crucial protein involved in the regulation of gene expression. NCoA-3 belongs to the class of coactivator proteins that play a pivotal role in the transcriptional activation of genes by nuclear receptors, such as steroid hormone receptors and other transcription factors. NCoA-3 interacts with these receptors and enhances their transcriptional activity by recruiting various coactivator complexes and facilitating the assembly of transcriptional machinery. Inhibition of NCoA-3's function has garnered attention in the field of molecular biology and discovery due to its ability to modulate gene expression patterns in a variety of physiological and pathological contexts. NCoA-3 inhibitors represent a class of compounds or molecules that have been specifically designed or identified to disrupt or attenuate the interactions between NCoA-3 and its binding partners, including nuclear receptors. These inhibitors may function through various mechanisms, such as interfering with the coactivator's binding interface, preventing its recruitment to the transcriptional complex, or altering its conformation. By inhibiting NCoA-3, researchers aim to gain a better understanding of the molecular mechanisms underlying gene regulation and to identify novel targets. NCoA-3 inhibitors role as valuable research tools in elucidating the complexities of gene expression and transcriptional regulation is undeniable, providing insights that could eventually lead to the development of innovative strategies for addressing various biological processes and diseases.

Items 1 to 10 of 12 total

Display:

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Etoposide (VP-16)

33419-42-0sc-3512B
sc-3512
sc-3512A
10 mg
100 mg
500 mg
$51.00
$231.00
$523.00
63
(1)

Etoposide (VP-16) acts as a potent inhibitor of topoisomerase II, engaging in unique molecular interactions that stabilize the enzyme-DNA complex. This stabilization disrupts the normal DNA replication process, leading to increased DNA strand breaks. Its kinetic behavior showcases a dose-dependent response, with distinct effects on cellular cycle progression. The compound's hydrophobic characteristics facilitate its penetration into cellular membranes, enhancing its interaction with nuclear components and influencing chromatin dynamics.

Resveratrol

501-36-0sc-200808
sc-200808A
sc-200808B
100 mg
500 mg
5 g
$80.00
$220.00
$460.00
64
(2)

Resveratrol is a natural polyphenolic compound found in grapes and berries. It has been shown to modulate various signaling pathways, potentially leading to the downregulation of NCoA-3 expression through epigenetic mechanisms.

Curcumin

458-37-7sc-200509
sc-200509A
sc-200509B
sc-200509C
sc-200509D
sc-200509F
sc-200509E
1 g
5 g
25 g
100 g
250 g
1 kg
2.5 kg
$37.00
$69.00
$109.00
$218.00
$239.00
$879.00
$1968.00
47
(1)

Curcumin, the active ingredient in turmeric, has anti-inflammatory and antioxidant properties. It may inhibit NCoA-3 expression by interfering with signaling pathways involved in inflammation and cellular proliferation.

D,L-Sulforaphane

4478-93-7sc-207495A
sc-207495B
sc-207495C
sc-207495
sc-207495E
sc-207495D
5 mg
10 mg
25 mg
1 g
10 g
250 mg
$153.00
$292.00
$489.00
$1325.00
$8465.00
$933.00
22
(1)

DL-Sulforaphane has demonstrated potential to modulate gene expression. It may downregulate NCoA-3 expression through its effects on epigenetic modifications and transcriptional regulation.

Quercetin

117-39-5sc-206089
sc-206089A
sc-206089E
sc-206089C
sc-206089D
sc-206089B
100 mg
500 mg
100 g
250 g
1 kg
25 g
$11.00
$17.00
$110.00
$250.00
$936.00
$50.00
33
(2)

Quercetin is a flavonoid with antioxidant properties. It may inhibit NCoA-3 expression by modulating signaling pathways and reducing oxidative stress, leading to changes in gene expression patterns.

(−)-Epigallocatechin Gallate

989-51-5sc-200802
sc-200802A
sc-200802B
sc-200802C
sc-200802D
sc-200802E
10 mg
50 mg
100 mg
500 mg
1 g
10 g
$43.00
$73.00
$126.00
$243.00
$530.00
$1259.00
11
(1)

As the main catechin in green tea, epigallocatechin gallate has antioxidant and anti-inflammatory properties. It may downregulate NCoA-3 expression by inhibiting pathways involved in inflammation and cellular growth.

Ellagic Acid, Dihydrate

476-66-4sc-202598
sc-202598A
sc-202598B
sc-202598C
500 mg
5 g
25 g
100 g
$58.00
$95.00
$245.00
$727.00
8
(1)

Found in fruits like berries and pomegranates, ellagic acid has antioxidant properties. It may downregulate NCoA-3 expression by influencing epigenetic modifications and altering gene expression patterns.

Indole-3-carbinol

700-06-1sc-202662
sc-202662A
sc-202662B
sc-202662C
sc-202662D
1 g
5 g
100 g
250 g
1 kg
$39.00
$61.00
$146.00
$312.00
$1032.00
5
(1)

Present in cruciferous vegetables, indole-3-carbinol may modulate estrogen metabolism and receptor signaling, potentially leading to reduced NCoA-3 expression.

Luteolin

491-70-3sc-203119
sc-203119A
sc-203119B
sc-203119C
sc-203119D
5 mg
50 mg
500 mg
5 g
500 g
$27.00
$51.00
$101.00
$153.00
$1925.00
40
(1)

Luteolin is a flavonoid with anti-inflammatory and antioxidant properties. It may inhibit NCoA-3 expression by modulating cellular signaling pathways involved in inflammation and gene transcription.

Apigenin

520-36-5sc-3529
sc-3529A
sc-3529B
sc-3529C
sc-3529D
sc-3529E
sc-3529F
5 mg
100 mg
1 g
5 g
25 g
100 g
1 kg
$33.00
$214.00
$734.00
$1151.00
$2348.00
$3127.00
$5208.00
22
(1)

Apigenin is a flavonoid found in many fruits and vegetables. It may downregulate NCoA-3 expression through its effects on signaling pathways and transcription factors involved in cellular growth and differentiation.