Ncapg Activators
The class of compounds identified as potential NCAPG activators encompasses a wide range of chemicals that are understood to affect the cellular environment and processes indirectly influencing the activity of the protein NCAPG-a critical component of the condensin complex involved in mitotic chromosome condensation. NCAPG does not have direct chemical activators due to its functional role within a protein complex; therefore, the activators in question modulate cellular pathways that could lead to an enhanced activity or increased necessity for the condensin complex function. The chemicals in this class include those that modulate cell cycle checkpoints and gene expression, such as caffeine, which influences cAMP levels and PKA activity, potentially affecting cell cycle-related proteins that interact with NCAPG. Similarly, forskolin raises cAMP levels, retinoic acid and Cholecalciferol act as transcriptional regulators, and resveratrol impacts AMPK pathways, all of which can have a downstream effect on the cell cycle and chromosomal dynamics. The molecular mechanisms by which these changes might impact NCAPG are through the altered phosphorylation states or through the modulation of gene expression patterns that govern the assembly or activity of the condensin complex.
Furthermore, some of the chemicals act by changing the chromatin landscape, such as trichostatin A and sodium butyrate, both HDAC inhibitors. By altering chromatin structure, these compounds could indirectly affect the access or requirement of NCAPG during chromosome condensation. Cyclosporin A and lithium chloride, in contrast, impact cellular signaling pathways that indirectly influence the cell cycle and mitotic events. Oxaliplatin and paclitaxel, on the other hand, affect DNA structure and stability, potentially leading to an indirect demand on the condensin complex for chromosomal maintenance and segregation. Collectively, these compounds form a unique class of indirect NCAPG activators that function through a diverse set of cellular mechanisms, ultimately influencing mitotic processes and chromosome condensation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine indirectly activates NCAPG through the modulation of the cell cycle. By inhibiting phosphodiesterases and increasing cAMP levels, caffeine affects the activity of cAMP-dependent protein kinase (PKA), which can then phosphorylate proteins involved in cell cycle regulation, potentially influencing the condensin complex activity and thus NCAPG function during mitosis. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG, a catechin found in green tea, has been reported to influence several signaling pathways, including those linked to cell cycle control. It is plausible that EGCG could modify the functionality of NCAPG by affecting upstream kinases or phosphatases that regulate the condensin complex, although the direct pathway is not clearly established. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid, a metabolite of vitamin A, regulates gene expression by activating nuclear receptors. It can influence the cell cycle and has the potential to affect proteins like NCAPG by altering the expression of genes encoding for proteins that interact with or regulate the condensin complex. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Cholecalciferol, through its active metabolite calcitriol, binds to the vitamin D receptor and influences gene expression. It could indirectly affect NCAPG by modifying the expression of genes that code for regulatory proteins involved in chromosome condensation and segregation. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is known to influence sirtuins and AMP-activated protein kinase (AMPK) pathways that can have downstream effects on cell cycle regulation. Therefore, resveratrol might influence NCAPG activity indirectly through these pathways and their impact on the condensin complex. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $63.00 $92.00 $250.00 $485.00 $1035.00 $2141.00 | 69 | |
Cyclosporin A, a calcineurin inhibitor, affects T-cell activation and may influence cell cycle progression in other cell types as well. This could potentially lead to changes in the regulation of proteins, such as NCAPG, which are involved in mitosis, although the precise interaction is not defined. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride can activate the Wnt signaling pathway by inhibiting GSK-3, which may influence cell cycle and mitotic processes. Although the effect on NCAPG is not direct, the modulation of GSK-3 activity might have a downstream impact on the condensin complex function. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A inhibits histone deacetylases (HDACs) and can alter chromatin structure, which may affect chromosome condensation processes and indirectly influence NCAPG activity in the condensin complex. | ||||||
Oxaliplatin | 61825-94-3 | sc-202270 sc-202270A | 5 mg 25 mg | $112.00 $394.00 | 8 | |
Oxaliplatin is a platinum-based compound that causes DNA crosslinking and can affect DNA repair mechanisms. While not an activator of NCAPG per se, it may indirectly necessitate enhanced activity of chromosome condensation mechanisms, involving NCAPG as part of the cellular response. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate is an HDAC inhibitor that can lead to changes in chromatin structure and gene expression. This alteration in chromatin dynamics could possibly affect the functionality of the condensin complex which includes NCAPG, although the direct mechanism remains elusive. | ||||||