Ncapg Inhibitors
Inhibitors of Ncapg are not a chemical class in themselves, as Ncapg does not have a direct set of known chemical inhibitors. Instead, the compounds listed above are chemicals that can affect the function of Ncapg indirectly by disrupting cellular processes or structures upon which Ncapg-dependent activities rely. The majority of these compounds target DNA replication and repair enzymes or alter the chromatin structure, both of which are essential for proper chromosome condensation and segregation, processes in which Ncapg plays a significant role. For instance, inhibitors of topoisomerase enzymes, such as amsacrine, camptothecin, etoposide, and podophyllotoxin, can lead to DNA damage or interfere with the replication process, which would subsequently impact the function of the condensin complex, including Ncapg. Similarly, compounds like paclitaxel and vincristine disrupt microtubule dynamics, which are crucial for chromosome segregation and indirectly for the role of Ncapg in this process.
The compounds that target DNA itself, such as alkylating agents chlorambucil and mitomycin C, or DNA binding compounds like mithramycin A and pentamidine, affect the structure and integrity of DNA, thereby influencing the condensin complex's ability to condense chromosomes properly. The alteration of chromatin structure by trichostatin A, an HDAC inhibitor, also indirectly affects Ncapg by modifying the histone acetylation status, thus affecting chromatin condensation and transcription. These chemicals bring about changes in the cellular environment that can hinder the normal function of Ncapg within the condensin complex, although they do not directly target the protein itself.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Amsacrine hydrochloride | 54301-15-4 | sc-214540 | 10 mg | $232.00 | ||
Amsacrine is an acridine derivative that intercalates into DNA and inhibits topoisomerase II, an enzyme crucial for DNA replication and transcription. By interfering with topoisomerase II, it can indirectly affect the function of Ncapg, as proper chromosome condensation requires DNA processing. | ||||||
Chlorambucil | 305-03-3 | sc-204682 sc-204682A | 250 mg 1 g | $51.00 $120.00 | 3 | |
Chlorambucil is an alkylating agent that can induce DNA cross-linking, leading to disruptions in DNA replication and transcription. This can affect the condensin complex's ability to condense chromosomes by altering the DNA structure that Ncapg acts upon. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
Camptothecin is a topoisomerase I inhibitor that stabilizes the DNA-topoisomerase I complex, preventing the relegation of single-strand DNA breaks essential for DNA replication. This can lead to chromosomal mis-segregation and indirectly affect Ncapg's role in chromosome condensation. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Etoposide is a topoisomerase II inhibitor that leads to the formation of cleavable complexes, causing DNA strand breaks. This can hinder the chromosomal processes in which Ncapg is involved, resulting in an indirect inhibition effect. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $54.00 | 6 | |
Mithramycin A binds to GC-rich sequences in DNA, inhibiting RNA polymerase and affecting transcription. As transcription is vital for chromosome structure and function, this can indirectly influence Ncapg's role in chromosome condensation. | ||||||
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $65.00 $99.00 $140.00 | 85 | |
Mitomycin C is a DNA cross-linking agent that can inhibit DNA synthesis and function. By disrupting DNA structure, Mitomycin C can indirectly affect the processes in which Ncapg is involved. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Paclitaxel stabilizes microtubules and inhibits their disassembly, affecting mitotic spindle function. Since the condensin complex, including Ncapg, is important for proper chromosome segregation, paclitaxel's effects on the spindle can indirectly impact Ncapg's function. | ||||||
Pentamidine | 100-33-4 | sc-208158 sc-208158A | 25 mg 50 mg | $373.00 $557.00 | ||
Pentamidine is a DNA minor groove binder that can interfere with DNA replication and other DNA-dependent processes. This can indirectly inhibit the function of the condensin complex, including Ncapg's role in chromosome condensation. | ||||||
Podophyllotoxin | 518-28-5 | sc-204853 | 100 mg | $82.00 | 1 | |
Podophyllotoxin is a topoisomerase II inhibitor and can prevent the religation of DNA strands. This disrupts the DNA replication process and can indirectly inhibit the role of Ncapg in the condensation of chromosomes. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase (HDAC) inhibitor that alters chromatin structure, affecting transcription. By changing the chromatin landscape, Trichostatin A can indirectly influence the function of Ncapg. | ||||||