NAT-15 Activators
NAT-15 activators comprise a diverse set of chemical compounds that indirectly enhance the functional activity of NAT-15 through various signaling pathways. Forskolin and 8-Bromo-cAMP both increase cellular cAMP levels, leading to the activation of PKA which may phosphorylate NAT-15 or its associated regulatory proteins, resulting in heightened activity. Similarly, PMA as a PKC activator, and Rolipram as a PDE4 inhibitor, also elevate the phosphorylation status within the cell which could indirectly result in the enhanced activity of NAT-15. Ionomycin and A23187, both calcium ionophores, raise intracellular calcium levels and can potentially activate calcium-dependent kinases that modify the activity or stability of NAT-15. Spermine, while primarily known for its role in modulating ion channels, may affect NAT-15 by altering its local cellular environment, thereby influencing its functional state.
The activity of NAT-15 is further influenced by the modulation of various kinase signals. EGCG, as a kinase inhibitor, can relax the phosphorylation-based inhibition of NAT-15, leading to its enhanced activity. LY294002, by inhibiting PI3K, and SB216763, by inhibiting GSK-3, bothalter downstream signaling in a way that could indirectly facilitate an increase in NAT-15 activity through changes in the phosphorylation landscape.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is an adenylate cyclase activator, leading to an increase in cAMP levels. Elevated cAMP activates PKA, which could phosphorylate NAT-15 or associated regulatory factors, thereby enhancing its activity indirectly. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium concentration, potentially activating calcium-dependent protein kinases that modify NAT-15 activity or stability. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC), which can phosphorylate substrates that may include NAT-15 or proteins in the NAT-15 regulatory pathway, thereby enhancing its activity. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
8-Bromo-cAMP is a cell-permeable cAMP analog that activates PKA, which in turn could enhance NAT-15 activity through phosphorylation of NAT-15 or related proteins. | ||||||
Spermine | 71-44-3 | sc-212953A sc-212953 sc-212953B sc-212953C | 1 g 5 g 25 g 100 g | $61.00 $196.00 $277.00 $901.00 | 1 | |
Spermine can modulate ion channels and may indirectly influence the local cellular environment of NAT-15, potentially affecting its conformation and enhancing its activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is a polyphenol that can inhibit certain protein kinases, potentially reducing phosphorylation-based inhibition of NAT-15, leading to its enhanced activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor, which could lead to altered AKT signaling and potentially increase the activity of NAT-15 through indirect pathway modulation. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A is a serine/threonine phosphatase inhibitor that could enhance NAT-15 activity by preventing dephosphorylation of NAT-15 or associated regulatory proteins. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram is a selective inhibitor of phosphodiesterase 4 (PDE4), leading to an increase in cAMP levels and subsequent activation of PKA, which might then enhance NAT-15 activity. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $105.00 $242.00 | 36 | |
Bisindolylmaleimide I is a specific inhibitor of PKC, which could shift the balance of cellular phosphorylation events, potentially enhancing NAT-15 activity by modifying its regulatory network. | ||||||