NANS Activators
NANS activators encompass a class of compounds that, through various biochemical mechanisms, are postulated to increase the enzymatic activity of sialic acid synthase. These compounds do not activate NANS directly but can affect the cellular metabolic state, substrate availability, or energy balance, which in turn can enhance the pathway of sialic acid synthesis where NANS plays a critical role. Compounds like NMN and Acetyl-CoA are pivotal in increasing the cellular pools of key metabolites and energy carriers. The availability of these metabolites may upregulate the biosynthesis of the precursors to sialic acid, thus potentially increasing the activity of NANS.
Further, compounds such as citric acid, pyruvate, and Glucosamine serve as integral players in metabolic pathways that can contribute to the synthesis of UDP-GlcNAc, a direct precursor for sialic acid production. Ensuring a sufficient supply of such precursors can be a determinant of the activity of NANS. Vitamins and cofactors such as biotin, folate, vitamin B12, and pantothenate are crucial for maintaining the metabolic processes that provide the building blocks for sialic acid synthesis. Their presence in sufficient quantities is essential for the optimal functioning of the biosynthetic pathway and, by extension, could enhance NANS activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
β-Nicotinamide mononucleotide | 1094-61-7 | sc-212376 sc-212376A sc-212376B sc-212376C sc-212376D | 25 mg 100 mg 1 g 2 g 5 g | $92.00 $269.00 $337.00 $510.00 $969.00 | 4 | |
NMN is a precursor in the biosynthesis of NAD+, which is essential for metabolic processes and can enhance the bioenergetic state of cells, potentially upregulating the sialic acid biosynthesis pathway and NANS activity. | ||||||
Acetyl coenzyme A trisodium salt | 102029-73-2 | sc-210745 sc-210745A sc-210745B | 1 mg 5 mg 1 g | $46.00 $80.00 $5712.00 | 3 | |
Acetyl-CoA is a key substrate in numerous biosynthetic pathways. An increase in acetyl-CoA concentration can drive the production of N-acetylmannosamine (ManNAc), a precursor to sialic acid, potentially increasing NANS activity. | ||||||
Citric Acid, Anhydrous | 77-92-9 | sc-211113 sc-211113A sc-211113B sc-211113C sc-211113D | 500 g 1 kg 5 kg 10 kg 25 kg | $49.00 $108.00 $142.00 $243.00 $586.00 | 1 | |
Citric acid is a central metabolite in the tricarboxylic acid cycle and can increase the pool of available acetyl-CoA, which in turn could elevate the substrate availability for NANS. | ||||||
Pyruvic acid | 127-17-3 | sc-208191 sc-208191A | 25 g 100 g | $40.00 $94.00 | ||
Pyruvate is a key intermediate in glycolysis and can be converted into acetyl-CoA, enhancing the substrate pool for sialic acid synthesis, thereby possibly increasing NANS activity. | ||||||
D-Glucosamine | 3416-24-8 | sc-278917A sc-278917 | 1 g 10 g | $197.00 $764.00 | ||
Glucosamine is an amino sugar that can contribute to the biosynthesis of UDP-N-acetylglucosamine, which is a substrate for sialic acid synthesis, potentially activating NANS. | ||||||
D-Mannose | 3458-28-4 | sc-211180 sc-211180A | 100 g 250 g | $101.00 $158.00 | 1 | |
Directly supplying N-acetylmannosamine (ManNAc) can increase substrate availability for NANS, thereby enhancing its activity. | ||||||
Uridine | 58-96-8 | sc-296685 sc-296685A | 1 g 25 g | $60.00 $98.00 | 1 | |
Uridine can contribute to the synthesis of uridine diphosphate N-acetylglucosamine (UDP-GlcNAc), which is a precursor in the sialic acid synthesis pathway, potentially enhancing NANS activity. | ||||||
N-Acetyl-D-glucosamine | 7512-17-6 | sc-286377 sc-286377B sc-286377A | 50 g 100 g 250 g | $92.00 $159.00 $300.00 | 1 | |
GlcNAc can be converted into ManNAc through enzymatic pathways, which would then be available as a substrate for NANS. | ||||||
D-(+)-Biotin | 58-85-5 | sc-204706 sc-204706A sc-204706B | 1 g 5 g 25 g | $40.00 $105.00 $326.00 | 1 | |
Biotin acts as a coenzyme for carboxylases that can contribute to the synthesis of metabolic intermediates, potentially increasing the substrate availability for NANS. | ||||||
Folic Acid | 59-30-3 | sc-204758 | 10 g | $72.00 | 2 | |
Folate participates in one-carbon metabolism and could potentially provide the methyl group for the synthesis of sialic acid, indirectly supporting NANS activity. | ||||||