NALP6 Inhibitors
NALP6, also known as NLRP6, is a member of the NOD-like receptor (NLR) family, which plays a crucial role in innate immunity and inflammation through its involvement in the assembly of inflammasomes. These multi-protein intracellular complexes are pivotal in the host defense system, mediating the activation of caspase-1 and the subsequent processing and secretion of pro-inflammatory cytokines like IL-1β and IL-18. NALP6 is expressed in multiple tissues, with significant expression in the gastrointestinal tract, where it contributes to maintaining mucosal integrity, shaping the composition of the gut microbiota, and regulating inflammatory responses. By modulating the activity of inflammasomes, NALP6 influences various physiological processes, including epithelial repair, barrier function, and the containment of microbial communities within the gut. This regulatory role underscores the importance of NALP6 in preserving tissue homeostasis and mitigating pathological inflammation that can lead to chronic inflammatory diseases.
The inhibition of NALP6 involves mechanisms that directly or indirectly reduce its activity or expression, thereby modulating inflammasome assembly and function. One primary approach to inhibiting NALP6 activity is through the interference with its ability to oligomerize or interact with other inflammasome components, such as ASC and procaspase-1. This can be achieved by targeting the NALP6 protein itself or its upstream regulators and downstream effectors. Another mechanism involves the modulation of signaling pathways that influence NALP6 expression, such as NF-κB and MAPK pathways, which are critical in the cellular response to inflammation and stress. Additionally, post-translational modifications of NALP6, including phosphorylation, ubiquitination, and sumoylation, can also impact its stability and function, offering another layer of regulation that could be targeted for inhibition. These mechanisms collectively provide a framework for understanding how NALP6 activity can be downregulated, highlighting the complex interplay between innate immune signaling pathways and the maintenance of immune homeostasis.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $79.00 $300.00 | 32 | |
Parthenolide inhibits NF-κB, a transcription factor involved in inflammatory responses. By suppressing NF-κB, Parthenolide can indirectly reduce the expression of NLRP6, which is regulated in part by NF-κB-driven inflammatory signaling. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
BAY 11-7082 inhibits IκBα phosphorylation, thereby blocking NF-κB activation. This inhibition can lead to reduced expression of NLRP6, as its expression is modulated through NF-κB signaling pathways. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane activates Nrf2, a transcription factor that modulates antioxidant responses. By inducing Nrf2, Sulforaphane can alter cellular redox states, potentially impacting NLRP6 activity or expression, which is sensitive to redox changes. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin exerts anti-inflammatory effects partly by inhibiting NF-κB. This inhibition can lead to a decrease in NLRP6 expression, as NF-κB is a known regulator of inflammasome components, including NLRP6. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol, a SIRT1 activator, can modulate multiple signaling pathways, including those that regulate inflammation. Through its influence on SIRT1, Resveratrol may indirectly modulate NLRP6 activity, given the role of SIRT1 in inflammatory responses. | ||||||
Anakinra | 143090-92-0 | sc-507486 | 10 mg | $795.00 | ||
Anakinra is an IL-1 receptor antagonist. By blocking IL-1 signaling, Anakinra can indirectly modulate NLRP6, as NLRP6 is part of the inflammasome complex that processes IL-1. | ||||||
Glyburide (Glibenclamide) | 10238-21-8 | sc-200982 sc-200982A sc-200982D sc-200982B sc-200982C | 1 g 5 g 25 g 100 g 500 g | $45.00 $60.00 $115.00 $170.00 $520.00 | 36 | |
Glyburide, also known as Glibenclamide, inhibits NLRP3 inflammasome activation. By targeting this specific inflammasome component, Glyburide may indirectly affect NLRP6 activity, as NLRP6 can form complexes with NLRP3 in certain cellular contexts. | ||||||
Andrographolide | 5508-58-7 | sc-205594 sc-205594A | 50 mg 100 mg | $15.00 $39.00 | 7 | |
Andrographolide suppresses NF-κB activation. This suppression can lead to a decrease in NLRP6 expression or activity, as NF-κB signaling is involved in the regulation of inflammasome components, including NLRP6. | ||||||
Apigenin | 520-36-5 | sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F | 5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg | $32.00 $210.00 $720.00 $1128.00 $2302.00 $3066.00 $5106.00 | 22 | |
Apigenin has anti-inflammatory properties and can inhibit NF-κB. This inhibition may lead to decreased NLRP6 expression or activity, as NLRP6 is regulated by NF-κB-driven pathways in certain cellular environments. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
Capsaicin modulates transient receptor potential (TRP) channels. By influencing TRP channels and associated calcium signaling, Capsaicin can indirectly affect NLRP6, which is sensitive to changes in intracellular calcium levels. | ||||||