NAF1 Inhibitors
NAF1 inhibitors belong to a class of chemical compounds designed to selectively target and modulate the activity of the NAF1 protein. The NAF1 protein, also known as Nuclear Assembly Factor 1, plays a crucial role in the regulation of nuclear envelope assembly and maintenance. It is involved in the biogenesis of the nuclear envelope, a fundamental cellular structure that separates the nucleus from the cytoplasm. NAF1 inhibitors are specifically designed to interfere with the function of NAF1, aiming to achieve a controlled modulation of nuclear envelope dynamics.
The chemical structure of NAF1 inhibitors is meticulously crafted to interact with the active sites or binding pockets on the NAF1 protein, disrupting its normal activity. By inhibiting NAF1, these compounds may impact the intricate processes associated with nuclear envelope assembly and maintenance. This targeted interference could have implications for cellular function, particularly in the context of nuclear organization and integrity. Researchers are actively investigating the mechanisms by which NAF1 inhibitors influence cellular processes, shedding light on the intricate details of nuclear envelope dynamics. As our understanding of these compounds advances, it opens avenues for potential applications in various scientific domains.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A potent inhibitor of phosphoinositide 3-kinases (PI3K), LY294002 leads to a blockade in the PI3K/Akt signaling pathway. This can result in reduced activity of NAF1 if PI3K is involved in its activation or stability. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is an inhibitor of mitogen-activated protein kinase kinase (MEK), which acts upstream of the MAPK/ERK pathway. Inhibition of MEK may indirectly decrease NAF1 activity if NAF1 is regulated by ERK signaling. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 specifically inhibits p38 MAP kinase, which is involved in stress responses. If NAF1 is activated or stabilized as part of a stress response pathway, SB203580 could reduce its activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits the mammalian target of rapamycin (mTOR), which is crucial for protein synthesis and cell growth. Inhibition of mTOR could lead to downregulation of NAF1 if it is a downstream target. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a selective inhibitor of MEK1/2, preventing the activation of MAPK/ERK pathway. Consequently, NAF1 activity may be diminished if it relies on MEK/ERK signaling for its function. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK), which is involved in cellular stress and apoptotic processes. NAF1 function could be decreased if it is associated with JNK signaling. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
A proteasome inhibitor, Bortezomib could reduce NAF1 levels by preventing the degradation of regulatory proteins that may keep NAF1 activity in check, thereby indirectly decreasing its functional activity. | ||||||
WZ4003 | 1214265-58-3 | sc-473979 | 5 mg | $300.00 | ||
WZ4003 selectively inhibits NUAK family SNF1-like kinase 1 (NUAK1), which can influence cellular metabolism and stress responses. If NAF1 is regulated by NUAK1, its activity could be indirectly inhibited by WZ4003. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $150.00 $349.00 | 15 | |
An Aurora kinase inhibitor, ZM-447439 may affect cell cycle progression. If NAF1 is involved in cell cycle regulation through Aurora kinases, its activity could be reduced by this inhibitor. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is another PI3K inhibitor, leading to the inhibition of the AKT signaling pathway. This could lead to a decrease in NAF1 activity if NAF1 is functionally connected to the PI3K/AKT pathway. | ||||||