MYL5 Inhibitors
MYL5 inhibitors are a class of chemical compounds that specifically target and inhibit the activity of the myosin light chain 5 (MYL5) protein, which is part of the myosin family. Myosin proteins play a critical role in cellular processes such as cytoskeletal organization, intracellular transport, and muscle contraction by interacting with actin filaments. The MYL5 protein, in particular, is one of the regulatory light chains that modulate myosin function by influencing the ATPase activity of the myosin motor domain. By inhibiting MYL5, these compounds interfere with the regulation of myosin's interaction with actin, which can lead to changes in cellular contractility, motility, and mechanical properties. These inhibitors can be highly selective or broad, depending on their mechanism of binding and specificity toward the MYL5 regulatory site.
MYL5 inhibitors often feature complex chemical backbones that allow them to effectively bind to the target protein, either through covalent or non-covalent interactions. These inhibitors may target the active site or allosteric sites of MYL5, influencing its conformational stability or its ability to bind to other molecules, such as actin. By altering the phosphorylation state or conformational dynamics of MYL5, these compounds can affect the overall myosin motor function in various cellular environments. Research into MYL5 inhibitors often explores their interactions with other proteins within the cytoskeletal system, allowing for a better understanding of how they modulate cellular processes like migration, adhesion, and contraction. Through advanced structural and biochemical studies, scientists can gain insights into the specific binding affinities and inhibitory profiles of these molecules.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A could downregulate MYL5 by preventing the deacetylation of histone proteins, leading to a less condensed chromatin state around the MYL5 gene, which is normally associated with reduced transcription. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This compound might decrease the expression of MYL5 by incorporating into DNA and disrupting the methylation pattern at the MYL5 gene promoter, which is often correlated with silenced gene expression. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $131.00 $515.00 | 2 | |
RG 108 could reduce MYL5 expression levels by blocking DNA methyltransferases, leading to hypomethylation of the MYL5 promoter region and potentially altering the binding affinity of transcriptional repressors. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Actinomycin D may inhibit MYL5 synthesis by intercalating between DNA base pairs at the MYL5 locus and stalling RNA polymerase during transcription, leading to a decrease in MYL5 mRNA levels. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin could indirectly reduce MYL5 levels by inhibiting the mTOR signaling pathway, which may cause a general decrease in cap-dependent mRNA translation, affecting proteins including MYL5. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
Cycloheximide may lead to a decrease in MYL5 protein by inhibiting the peptidyl transferase activity of the ribosome, thus halting elongation during protein synthesis and reducing overall MYL5 accumulation. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $269.00 $1050.00 | 26 | |
α-Amanitin could specifically inhibit the expression of MYL5 by tightly binding to RNA polymerase II and preventing the elongation phase of MYL5 mRNA synthesis. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $55.00 | 6 | |
Mithramycin A might decrease MYL5 expression by binding to G-C rich DNA sequences and sterically hindering the binding of transcription factors and the transcriptional machinery to the MYL5 promoter. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Chloroquine has the potential to inhibit MYL5 transcription by intercalating into DNA and RNA, which would obstruct the replication and transcription processes essential for the production of MYL5 mRNA. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
JQ1 might lead to downregulation of MYL5 by competitively inhibiting the binding of BET bromodomain proteins to acetylated histones, thus altering the expression of genes including MYL5 by shifting the chromatin structure to a more repressive state. | ||||||