Myf-5 Activators
The regulation of Myf-5, a key player in myogenic differentiation, is an intricate dance of molecular signals orchestrated by a diverse array of chemical modulators. These activators directly or indirectly stimulate Myf-5, offering insights into the multifaceted regulatory networks governing skeletal muscle formation. One notable group of activators includes those targeting the AMP-activated protein kinase (AMPK), such as AICAR, Salidroside, A769662, and Trolox. By activating AMPK, these chemicals contribute to cellular energy balance, indirectly fostering an environment conducive to Myf-5 expression. This highlights the pivotal role of energy-sensing pathways in the modulation of Myf-5 and the initiation of myogenic differentiation. Peroxisome proliferator-activated receptor-delta (PPAR-δ) agonists, exemplified by GW501516, offer another avenue for Myf-5 activation. These chemicals stimulate PPAR-δ, influencing mitochondrial biogenesis and fatty acid metabolism. The resulting cellular alterations indirectly support Myf-5 by creating a microenvironment favorable for myogenic processes.
Heat shock protein 72 (Hsp72) activators, like BGP-15, contribute to Myf-5 activation by enhancing cellular stress responses. This reveals the interconnectedness of cellular protective mechanisms with the regulatory networks governing Myf-5 and myogenic differentiation. Inhibitors of the Arp2/3 complex, exemplified by CK-666, indirectly activate Myf-5 by modulating actin dynamics and cellular architecture. By impacting the structural basis of myogenic differentiation, these chemicals contribute to Myf-5 activation through the manipulation of cytoskeletal organization. The MEK inhibitor U0126 provides a unique perspective by indirectly activating Myf-5 through the dampening of the MAPK pathway. This inhibition releases constraints, allowing for the activation of Myf-5 and the initiation of myogenic processes. Calcium ionophores, such as Ionomycin, elevate intracellular calcium levels, indirectly activating Myf-5 through calcium-dependent signaling pathways. This underscores the importance of calcium dynamics in the regulatory landscape of Myf-5 and myogenic differentiation In summary, the activators of Myf-5 outlined in the table offer a nuanced exploration of the molecular landscape governing myogenic differentiation. Their diverse mechanisms of action underscore the complexity of cellular signaling networks that converge to regulate Myf-5 and illuminate avenues for further exploration into the dynamic processes shaping skeletal muscle development.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AMP-activated protein kinase (AMPK) activator. AICAR stimulates AMPK, promoting cellular energy balance. This indirectly activates Myf-5 by enhancing AMPK-mediated pathways that contribute to the regulatory network governing myogenic differentiation. | ||||||
GW501516 | 317318-70-0 | sc-202642 sc-202642A | 1 mg 5 mg | $82.00 $179.00 | 28 | |
Peroxisome proliferator-activated receptor-delta (PPAR-δ) agonist. GW501516 activates PPAR-δ, influencing mitochondrial biogenesis and fatty acid metabolism. Through PPAR-δ, this chemical can indirectly activate Myf-5 by modulating the cellular environment conducive to myogenic processes. | ||||||
Fasudil, Monohydrochloride Salt | 105628-07-7 | sc-203418 sc-203418A sc-203418B sc-203418C sc-203418D sc-203418E sc-203418F | 10 mg 50 mg 250 mg 1 g 2 g 5 g 10 g | $18.00 $33.00 $87.00 $168.00 $253.00 $496.00 $910.00 | 5 | |
Rho kinase (ROCK) inhibitor. Fasudil inhibits ROCK, indirectly activating Myf-5 by disrupting the RhoA/ROCK signaling pathway. This chemical modulates cytoskeletal dynamics and cellular tension, influencing the regulatory network governing myogenic differentiation. | ||||||
BGP-15 | 66611-37-8 | sc-507452 | 10 mg | $375.00 | ||
Heat shock protein 72 (Hsp72) activator. BGP-15 activates Hsp72, promoting cellular stress response pathways. Indirectly, this chemical supports Myf-5 activation by enhancing the protective functions of Hsp72, contributing to the cellular milieu conducive to myogenic differentiation. | ||||||
Salidroside | 10338-51-9 | sc-472942 | 50 mg | $360.00 | 1 | |
AMP-activated protein kinase (AMPK) activator. Salidroside activates AMPK, influencing cellular energy homeostasis. Through AMPK-mediated pathways, it indirectly activates Myf-5, contributing to the modulation of cellular processes that drive myogenic differentiation. | ||||||
CK 666 | 442633-00-3 | sc-361151 sc-361151A | 10 mg 50 mg | $321.00 $1040.00 | 5 | |
Arp2/3 complex inhibitor. CK-666 disrupts actin dynamics, indirectly activating Myf-5 by impacting cytoskeletal organization. This chemical modulates cellular architecture, influencing the structural basis of myogenic differentiation and contributing to Myf-5 activation. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
MEK inhibitor. U0126 indirectly activates Myf-5 by dampening the MAPK pathway. By inhibiting MEK, an upstream regulator of MAPK, this compound alters the signaling cascade, potentially releasing inhibitory constraints and allowing for the activation of Myf-5 and myogenic processes. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Calcium ionophore. Ionomycin elevates intracellular calcium levels, indirectly activating Myf-5 by influencing calcium-dependent signaling pathways. This chemical modulates calcium-dependent processes, contributing to the regulatory network governing Myf-5 and myogenic differentiation. | ||||||
A-769662 | 844499-71-4 | sc-203790 sc-203790A sc-203790B sc-203790C sc-203790D | 10 mg 50 mg 100 mg 500 mg 1 g | $184.00 $741.00 $1076.00 $3417.00 $5304.00 | 23 | |
AMP-activated protein kinase (AMPK) activator. A769662 activates AMPK, indirectly promoting Myf-5 activation by modulating cellular energy status. Through AMPK-mediated pathways, this chemical influences the regulatory network governing myogenic differentiation and enhances Myf-5 expression. | ||||||
Trolox | 53188-07-1 | sc-200810 sc-200810A sc-200810B sc-200810C sc-200810D | 500 mg 1 g 5 g 25 g 100 g | $38.00 $67.00 $235.00 $678.00 $1712.00 | 39 | |
Antioxidant. Trolox indirectly activates Myf-5 by mitigating oxidative stress. As an antioxidant, it modulates cellular redox balance, influencing signaling pathways related to Myf-5 activation. By reducing oxidative stress, Trolox contributes to the cellular environment conducive to myogenic differentiation. | ||||||