MuSK Inhibitors
MuSK inhibitors belong to a class of chemical compounds specifically designed to target and modulate the activity of muscle-specific kinase (MuSK), a receptor tyrosine kinase that plays a crucial role in the development and function of neuromuscular junctions. MuSK is essential for the proper formation and maintenance of neuromuscular synapses, where it interacts with agrin and other proteins to regulate signaling pathways involved in synapse formation and stability. Inhibiting MuSK activity may have possible implications in neuromuscular disorders, particularly myasthenia gravis, where autoantibodies against MuSK lead to impaired neuromuscular transmission. MuSK inhibitors can interfere with MuSK activation and downstream signaling, modulating neuromuscular junction development and function.
The specific mechanisms of action of MuSK inhibitors may involve various approaches, such as blocking MuSK's kinase activity or interfering with its interaction with ligands like agrin. Some MuSK inhibitors may be monoclonal antibodies specifically designed to bind to MuSK and impede its activation, while others could be small molecule compounds that inhibit MuSK's catalytic function. The study of MuSK inhibitors has provided valuable insights into the role of MuSK in neuromuscular biology and its contributions to synapse formation and stability. By exploring MuSK inhibitors, researchers can gain a better understanding of neuromuscular junction development and function, paving the way for strategies in neuromuscular disorders. Continued research in this area may lead to further discoveries about MuSK-related biology and its possible implications in various physiological and pathological conditions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that can suppress the PI3K-Akt pathway, thereby inhibiting the activation of MuSK | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is another PI3K inhibitor that can also suppress the PI3K-Akt pathway, leading to the inhibition of MuSK activation | ||||||
NIP 142 | 203002-58-8 | sc-478327 | 1 mg | $430.00 | ||
An experimental small molecule inhibitor of MUSK, studied for its effects on neuromuscular junction formation and function. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 is a Src family kinase inhibitor. By inhibiting Src kinases, PP2 can suppress the activation of MuSK | ||||||
Lapatinib | 231277-92-2 | sc-353658 | 100 mg | $412.00 | 32 | |
Lapatinib is an inhibitor of the tyrosine kinases EGFR and HER2. By inhibiting these kinases, Lapatinib can suppress the activation of MuSK | ||||||
Gefitinib | 184475-35-2 | sc-202166 sc-202166A sc-202166B sc-202166C | 100 mg 250 mg 1 g 5 g | $62.00 $112.00 $214.00 $342.00 | 74 | |
Gefitinib is another tyrosine kinase inhibitor that can inhibit EGFR, thereby suppressing the activation of MuSK | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a MEK inhibitor that can suppress the MAPK pathway, thereby inhibiting the activation of MuSK | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor that can suppress the MAPK pathway, thereby inhibiting the activation of MuSK | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a JNK inhibitor that can suppress the JNK pathway, thereby inhibiting the activation of MuSK | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is a ROCK inhibitor that can suppress the Rho-ROCK pathway, thereby inhibiting the activation of MuSK | ||||||