MuSK Antibody (1-YD2): sc-134398

MuSK Antibody (1-YD2) is a mouse monoclonal IgG2a kappa light chain antibody that detects MuSK protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-MuSK antibody (1-YD2) is available as the non-conjugated format. MuSK (muscle-specific kinase) plays a crucial role in the formation and maintenance of the neuromuscular junction, which is essential for effective communication between motor neurons and skeletal muscle fibers. MuSK (1-YD2) monoclonal antibody recognizes a receptor tyrosine kinase primarily expressed in skeletal muscle and vital for the clustering of acetylcholine receptors at the neuromuscular junction, thereby facilitating muscle contraction. MuSK is expressed at low levels in proliferating myoblasts but significantly upregulates during terminal differentiation and myotube fusion, highlighting its importance in muscle development. During embryonic stages, MuSK is present in developing muscle tissues, but expression diminishes in mature muscle, where MuSK is predominantly found at the neuromuscular junction. The human MuSK gene is located on chromosome 9q31.3, overlapping a region associated with the Fukuyama muscular dystrophy mutation, underscoring its relevance in muscle-related disorders.

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MuSK Antibody (1-YD2) References:

1. Growth factor signaling by receptor tyrosine kinases.  |  Schlessinger, J. and Ullrich, A. 1992. Neuron. 9: 383-91. PMID: 1326293
2. A novel putative tyrosine kinase receptor with oncogenic potential.  |  Janssen, JW., et al. 1991. Oncogene. 6: 2113-20. PMID: 1834974
3. Mechanisms associated with the pathogenicity of antibodies against muscle-specific kinase in myasthenia gravis.  |  Mori, S. and Shigemoto, K. 2013. Autoimmun Rev. 12: 912-7. PMID: 23537506
4. Muscle-specific kinase antibody positive myaesthenia gravis and multiple sclerosis co-presentation: a case report and literature review.  |  Sylvester, J., et al. 2013. J Neuroimmunol. 264: 130-3. PMID: 24041829
5. Structure and function of human amphiregulin: a member of the epidermal growth factor family.  |  Shoyab, M., et al. 1989. Science. 243: 1074-6. PMID: 2466334
6. Myasthenia gravis with muscle specific kinase antibodies mimicking amyotrophic lateral sclerosis.  |  Huijbers, MG., et al. 2016. Neuromuscul Disord. 26: 350-3. PMID: 27133662
7. IgG4 autoantibodies against muscle-specific kinase undergo Fab-arm exchange in myasthenia gravis patients.  |  Koneczny, I., et al. 2017. J Autoimmun. 77: 104-115. PMID: 27965060
8. Treating muscle-specific kinase myasthenia gravis from the inside out.  |  Huijbers, MG. and Verschuuren, JJGM. 2020. Neurol Neuroimmunol Neuroinflamm. 7: PMID: 31831572
9. Comparison of three methods for the detection of antibodies against muscle-specific kinase.  |  Luong, K., et al. 2024. J Immunol Methods. 526: 113627. PMID: 38311009
10. Receptor tyrosine kinase specific for the skeletal muscle lineage: expression in embryonic muscle, at the neuromuscular junction, and after injury.  |  Valenzuela, DM., et al. 1995. Neuron. 15: 573-84. PMID: 7546737
11. Identification of alternative exons, including a novel exon, in the tyrosine kinase receptor gene Etk2/tyro3 that explain differences in 5' cDNA sequences.  |  Biesecker, LG., et al. 1995. Oncogene. 10: 2239-42. PMID: 7784069
12. Overexpression of the Sky receptor tyrosine kinase at the cell surface or in the cytoplasm results in ligand-independent activation.  |  Taylor, IC., et al. 1995. Oncogene. 11: 2619-26. PMID: 8545119

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MuSK Antibody (1-YD2) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-MuSK Antibody (1-YD2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MuSK Antibody (1-YD2) Specifications

Alternate Product Name: MuSK

Product Clone Name: 1-YD2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 301-400

Epitope Target: MuSK

Epitope Species: human

Product Reactivity/Detection: MuSK

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for MuSK Antibody (1-YD2): N/A