MuSK Activators
MuSK Activators are a class of compounds that directly or indirectly enhance the functional activity of the protein called the muscle-specific kinase (MuSK). These compounds act via different pathways to positively regulate the activation of MuSK. Some of these compounds, such as Acetylcholine and Agrin, directly interact with MuSK or its associated proteins to trigger its activation. For instance, Acetylcholine binds the acetylcholine receptor, thereby initiating a signaling cascade that culminates in MuSK's activation. Similarly, Agrin binds to Lrp4, which then leads to MuSK's activation.
On the other hand, other MuSK Activators such as U0126, Forskolin, and Dibutyryl-cAMP, indirectly enhance MuSK activation by modulating other signaling pathways that ultimately affect MuSK. For instance, U0126 inhibits MEK1/2, thereby reducing the negative feedback regulation on MuSK by ERK1/2. Forskolin and Dibutyryl-cAMP act by increasing cAMP levels and directly activating PKA, respectively, leading to the phosphorylation and activation of MuSK. Other compounds like Staurosporine and Rapamycin inhibit protein kinases that negatively regulate MuSK, ensuring its activation.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is a potent inhibitor of mTOR, which negatively regulates MuSK. By inhibiting mTOR, rapamycin can enhance the activation of MuSK | ||||||
Adenosine 5′-Triphosphate, disodium salt | 987-65-5 | sc-202040 sc-202040A | 1 g 5 g | $39.00 $75.00 | 9 | |
ATP can bind to MuSK, leading to its autophosphorylation and activation. This process is crucial for the initiation of the downstream signaling cascade | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is a potent activator of adenylate cyclase, which can increase the levels of cAMP. The increased cAMP levels can enhance the activation of protein kinase A (PKA), which can phosphorylate and activate MuSK | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Dibutyryl-cAMP, a cell-permeable cAMP analog, can directly activate PKA, leading to the activation of MuSK | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Phorbol 12-myristate 13-acetate (PMA) is a potent activator of protein kinase C (PKC), which can phosphorylate and activate MuSK | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $96.00 $264.00 | 2 | |
Ionomycin is a calcium ionophore that can increase intracellular calcium levels. The increased calcium levels can activate calcium-calmodulin-dependent protein kinase II (CaMKII), which can phosphorylate and activate MuSK | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases, PP1 and PP2A. By inhibiting these phosphatases, okadaic acid can enhance the phosphorylation and activation of MuSK | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a broad-spectrum protein kinase inhibitor. It can inhibit several protein kinases that negatively regulate MuSK, leading to enhanced MuSK activation | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin is a potent activator of the JNK pathway. Activated JNK can phosphorylate and activate MuSK | ||||||