MUL1 Inhibitors
MUL1 inhibitors represent a class of small molecules that primarily target MUL1 (Mitochondrial E3 ubiquitin-protein ligase) enzymes, playing a crucial role in regulating mitochondrial dynamics and homeostasis within cells. These inhibitors are designed to modulate the activity of MUL1, a vital component of the mitochondrial quality control system responsible for maintaining mitochondrial health and function. MUL1 functions as an E3 ubiquitin ligase, which means it helps tag proteins for degradation by the proteasome or lysosome. Specifically, MUL1 is involved in ubiquitinating MFN1 and MFN2 (Mitofusin 1 and 2), proteins essential for mitochondrial fusion. By inhibiting MUL1, these compounds can interfere with the ubiquitination of MFN1 and MFN2, potentially promoting mitochondrial fusion and altering the balance of mitochondrial dynamics.
The disruption of mitochondrial dynamics has been implicated in various cellular processes and diseases, including neurodegenerative disorders. MUL1 inhibitors, therefore, hold promise as valuable tools for researchers studying the role of mitochondrial dynamics in these conditions. Additionally, the development of MUL1 inhibitors may shed light on the fundamental mechanisms governing mitochondrial regulation, providing insights into potential strategies in the future.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $79.00 $300.00 | 32 | |
This sesquiterpene lactone can disrupt NF-κB signaling, a pathway where MUL1 can have regulatory roles. | ||||||
Urolithin A | 1143-70-0 | sc-475514 sc-475514A sc-475514B sc-475514C | 25 mg 100 mg 1 g 5 g | $200.00 $450.00 $700.00 $1200.00 | 10 | |
As a mitophagy inducer, it might affect the same pathways regulated by MUL1. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
A proteasome inhibitor that can increase the levels of ubiquitinated proteins, indirectly affecting MUL1's role in ubiquitination. | ||||||
Sorafenib | 284461-73-0 | sc-220125 sc-220125A sc-220125B | 5 mg 50 mg 500 mg | $56.00 $260.00 $416.00 | 129 | |
A kinase inhibitor that can affect multiple signaling pathways, potentially altering MUL1 activity by changing the phosphorylation state of signaling proteins. | ||||||
Mdivi-1 | 338967-87-6 | sc-215291 sc-215291B sc-215291A sc-215291C | 5 mg 10 mg 25 mg 50 mg | $66.00 $124.00 $246.00 $456.00 | 13 | |
A selective inhibitor of mitochondrial division, which can indirectly affect MUL1's role in mitochondrial dynamics. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $62.00 $90.00 $299.00 $475.00 $1015.00 $2099.00 | 69 | |
An immunosuppressant that inhibits mitochondrial permeability transition pore (mPTP); it can indirectly modulate MUL1's roles in mitochondria. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $96.00 $250.00 $750.00 $1428.00 | 280 | |
An inhibitor of the V-ATPase, which can affect lysosomal function and thus potentially influence the mitophagic process regulated by MUL1. | ||||||
FCCP | 370-86-5 | sc-203578 sc-203578A | 10 mg 50 mg | $92.00 $348.00 | 46 | |
A mitochondrial uncoupler that can disrupt mitochondrial membrane potential, indirectly affecting MUL1's regulatory functions. | ||||||
Oligomycin A | 579-13-5 | sc-201551 sc-201551A sc-201551B sc-201551C sc-201551D | 5 mg 25 mg 100 mg 500 mg 1 g | $175.00 $600.00 $1179.00 $5100.00 $9180.00 | 26 | |
An ATP synthase inhibitor that can change mitochondrial dynamics, which MUL1 is known to influence. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $118.00 $320.00 $622.00 $928.00 $1234.00 | 38 | |
A PPARγ agonist that can modulate mitochondrial biogenesis and dynamics, thus potentially affecting MUL1's activity. | ||||||