Muc21 Activators
Muc21 is part of a family of mucin proteins that serve primarily as structural components of mucus, providing protective, lubricating, and cell-signaling functions. Muc21 activators encompass a class of chemicals that are not direct activators of the protein but are capable of indirectly influencing its expression or function by acting on various signaling pathways, transcription factors, or epigenetic mechanisms. These compounds, although not interacting with Muc21 directly, can modify the cellular environment or gene expression patterns in a manner that may result in increased levels or altered functionality of Muc21. The mechanisms by which these chemicals exert their influence vary widely, from affecting DNA methylation and histone acetylation to modulating specific receptor-mediated pathways and general signal transduction cascades.
Each compound has unique properties that can lead to changes in the expression or function of mucins, including Muc21, and they do so by either upregulating gene expression, altering the stability of the mucin transcripts, or modifying the cellular machinery that controls mucin secretion. These indirect activators can act through various pathways; for example, retinoic acid and dexamethasone influence gene expression through their interactions with nuclear receptors, while EGCG and curcumin can alter cell signaling pathways, leading toGiven the protein Muc21 (mucin 21, cell surface associated), there are no direct chemical activators that are specifically known to activate Muc21.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid, a metabolite of Vitamin A, can modulate gene expression by activating nuclear receptors which could lead to the upregulation of mucin gene expression, including Muc21. | ||||||
Butyric acid | 107-92-6 | sc-214640 sc-214640A | 1 kg 10 kg | $64.00 $177.00 | ||
Butyrate, a short-chain fatty acid, acts as a histone deacetylase inhibitor that can lead to hyperacetylation of histones, affecting chromatin structure and potentially increasing transcription of mucin genes such as Muc21. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
5-Aza-2'-deoxycytidine is a DNA methyltransferase inhibitor that can cause hypomethylation of DNA, potentially leading to the activation of silenced genes, including those related to mucin production. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG, a major component of green tea, can influence signal transduction pathways and might modulate the expression of mucins indirectly. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone, a synthetic glucocorticoid, can regulate gene expression including genes involved in mucin production, potentially affecting Muc21 levels indirectly. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride can inhibit glycogen synthase kinase-3 (GSK-3), which might impact mucin expression through Wnt signaling pathway alterations, indirectly influencing Muc21 expression. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane, an isothiocyanate derived from cruciferous vegetables, can activate the Nrf2 pathway, which may lead to upregulation of protective genes including mucins. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, a compound from turmeric, can modulate numerous signaling pathways and might indirectly influence mucin gene expression. | ||||||
Cholic acid | 81-25-4 | sc-255020 sc-255020A sc-255020B sc-255020C sc-255020D | 25 g 100 g 500 g 1 kg 5 kg | $49.00 $123.00 $578.00 $1018.00 $4570.00 | 11 | |
Bile acids can activate nuclear receptors like FXR, which in turn may regulate genes involved in mucin production, possibly affecting Muc21. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, a polyphenol found in grapes, can interact with multiple signaling pathways and could have an impact on mucin gene regulation. | ||||||