MTMR12 Inhibitors
MTMR12 inhibitors encompass a range of chemical compounds that influence mitochondrial function and energetics, indirectly affecting the activity of mitochondrial ribosome associated GTPase 1 (MTMR12). These compounds exert their effects through various mechanisms, including the inhibition of mitochondrial oxidative phosphorylation complexes, alteration of the mitochondrial redox state, and disruption of mitochondrial protein synthesis. For instance, certain compounds that target mitochondrial complexes I, III, and IV, such as those that impair the electron transport chain and proton gradient, lead to a decrease in ATP production and mitochondrial membrane potential, thus impacting the environment necessary for MTMR12's function. Others inhibit ATP synthase or activate AMP-activated protein kinase, thereby affecting the ATP availability and energy sensing within the mitochondria, which are critical for the operational dynamics of MTMR12.
Additional inhibitors work by modifying the synthesis or stability of proteins within the mitochondria or by influencing the prenylation and membrane associations of mitochondrial proteins. Some of these inhibitors bind directly to the mitochondrial ribosome, hindering the synthesis of proteins that are essential for mitochondrial function and potentially affecting the role of MTMR12 as a mitochondrial ribosome-associated factor. Moreover, compounds that alter the redox state within mitochondria can influence redox-sensitive processes and pathways that are involved in the regulation of MTMR12 activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Allopurinol | 315-30-0 | sc-207272 | 25 g | $131.00 | ||
This xanthine oxidase inhibitor reduces the production of uric acid, which can indirectly inhibit MTMR12 by decreasing oxidative stress and potentially modulating mitochondrial function. | ||||||
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $259.00 | 41 | |
As an inhibitor of mitochondrial complex I, Rotenone decreases mitochondrial electron transport, which can lead to reduced ATP synthesis and indirectly inhibit the activity of MTMR12 within the mitochondria. | ||||||
Antimycin A | 1397-94-0 | sc-202467 sc-202467A sc-202467B sc-202467C | 5 mg 10 mg 1 g 3 g | $55.00 $63.00 $1675.00 $4692.00 | 51 | |
By inhibiting mitochondrial complex III, Antimycin A disrupts electron transfer and can decrease the proton gradient, indirectly leading to the inhibition of MTMR12 function by affecting mitochondrial energy balance. | ||||||
Oligomycin | 1404-19-9 | sc-203342 sc-203342C | 10 mg 1 g | $149.00 $12495.00 | 18 | |
Oligomycin inhibits ATP synthase, which can lead to the inhibition of MTMR12 by lowering ATP availability within the mitochondria and affecting its GTPase activity. | ||||||
Auranofin | 34031-32-8 | sc-202476 sc-202476A sc-202476B | 25 mg 100 mg 2 g | $153.00 $214.00 $4000.00 | 39 | |
This inhibitor of thioredoxin reductase can indirectly inhibit MTMR12 by altering the redox state within mitochondria, potentially affecting redox-sensitive processes in which MTMR12 is involved. | ||||||
Carbonyl Cyanide m-Chlorophenylhydrazone | 555-60-2 | sc-202984A sc-202984 sc-202984B | 100 mg 250 mg 500 mg | $77.00 $153.00 $240.00 | 8 | |
A protonophore uncoupling agent that dissipates the proton gradient across the mitochondrial membrane; can indirectly inhibit MTMR12 by collapsing the mitochondrial membrane potential, thus affecting its functional activity. | ||||||
Tetracycline | 60-54-8 | sc-205858 sc-205858A sc-205858B sc-205858C sc-205858D | 10 g 25 g 100 g 500 g 1 kg | $63.00 $94.00 $270.00 $417.00 $634.00 | 6 | |
By interacting with the mitochondrial ribosome, Tetracycline can inhibit protein synthesis within mitochondria, which can indirectly affect the activity of MTMR12 as it is associated with the mitochondrial ribosome. | ||||||
Sodium azide | 26628-22-8 | sc-208393 sc-208393B sc-208393C sc-208393D sc-208393A | 25 g 250 g 1 kg 2.5 kg 100 g | $43.00 $155.00 $393.00 $862.00 $90.00 | 8 | |
This inhibitor of mitochondrial complex IV can indirectly inhibit MTMR12 by disrupting the electron transport chain and ATP synthesis, which is crucial for the energy-dependent functions of MTMR12. | ||||||
1,1-Dimethylbiguanide, Hydrochloride | 1115-70-4 | sc-202000F sc-202000A sc-202000B sc-202000C sc-202000D sc-202000E sc-202000 | 10 mg 5 g 10 g 50 g 100 g 250 g 1 g | $20.00 $43.00 $63.00 $156.00 $260.00 $510.00 $31.00 | 37 | |
Activates AMP-activated protein kinase (AMPK), which can indirectly inhibit MTMR12 by modulating cellular energy metabolism and potentially affecting the mitochondrial context in which MTMR12 operates. | ||||||
Doxycycline-d6 | 564-25-0 unlabeled | sc-218274 | 1 mg | $16500.00 | ||
Doxycycline binds to the mitochondrial ribosome and inhibits mitochondrial protein synthesis, which can indirectly inhibit the activity of MTMR12. | ||||||