Mtif3 Activators
Mtif3 Activators are a collection of chemical compounds that influence various cellular signaling pathways, indirectly augmenting the functional activity of the mitochondrial translational initiation factor, Mtif3. Compounds like Forskolin and A23187 (Calcimycin) target the cAMP/PKA and calcium-dependent signaling pathways respectively, which can lead to phosphorylation events and stress responses that may enhance the assembly and function of the mitochondrial ribosome involving Mtif3. PMA, a PKC activator, and the PI3K inhibitor LY294002, along with U0126 and SB203580, which are inhibitors of the MEK1/2 and p38 MAPK pathways, could indirectly increase the demand for mitochondrial protein synthesis, thereby enhancing Mtif3 activity. Rapamycin, by inhibiting mTOR signaling, may also promote mitochondrial biogenesis and thetranslation process, which may indirectly lead to heightened Mtif3 activity due to increased biogenesis requirements.
Moreover, compounds that affect mitochondrial respiration and ATP production, such as Rotenone, FCCP, Oligomycin, and Zinc Pyrithione, can create a compensatory response in the cell that enhances mitochondrial translation to maintain energy homeostasis, which would in turn enhance the role of Mtif3 in initiating mitochondrial protein synthesis. Resveratrol activates SIRT1, which is involved in promoting mitochondrial function and biogenesis, potentially leading to an increased need for mitochondrial translation that Mtif3 facilitates. Collectively, these Mtif3 Activators, through their varied actions on cellular signaling and metabolic pathways, support the upregulation of mitochondrial translation processes that are critical for cell function and survival. Each activator, by influencing specific pathways or cellular stress responses, indirectly contributes to the enhancement of Mtif3's involvement in the assembly and function of the mitochondrial ribosome, crucial for the synthesis of mitochondrial-encoded proteins.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylyl cyclase, increasing intracellular cAMP. Elevated cAMP in turn activates PKA, which could phosphorylate proteins involved in the mitochondrial translation process, potentially enhancing the activity of Mtif3 by facilitating assembly of the mitochondrial ribosome. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is an ionophore that increases intracellular calcium levels, which activates calcium-dependent signaling pathways. This could enhance the function of Mtif3 by influencing the mitochondrial stress response, where calcium signaling is known to modulate mitochondrial function. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which is involved in various signaling pathways. Activated PKC may indirectly enhance the function of Mtif3 by altering phosphorylation states of proteins that associate with the mitochondrial translation machinery. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that alters downstream AKT signaling. By inhibiting this pathway, it could shift the cellular energy balance towards oxidative phosphorylation, thereby potentially increasing the demand for Mtif3 activity in mitochondrial protein synthesis. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of MEK1/2, which indirectly may affect the ERK/MAPK pathway. This could lead to an increased reliance on mitochondrial function and thereby potentially enhance the functional activity of Mtif3 by increasing its demand in mitochondrial translation. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor. By inhibiting p38 MAPK, it may influence cellular stress responses, potentially leading to an increased requirement for mitochondrial translation and thereby enhancing the activity of Mtif3. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, which is involved in cell growth and metabolism regulation. This inhibition could increase mitochondrial biogenesis and translation, potentially enhancing the functional activity of Mtif3 as part of the mitochondrial ribosome. | ||||||
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $254.00 | 41 | |
Rotenone is an inhibitor of mitochondrial complex I. By inhibiting complex I, it may increase the demand for newly synthesized mitochondrial proteins, thereby potentially enhancing Mtif3 activity to compensate for impaired respiration. | ||||||
FCCP | 370-86-5 | sc-203578 sc-203578A | 10 mg 50 mg | $92.00 $348.00 | 46 | |
FCCP uncouples oxidative phosphorylation, which can lead to an increased demand for mitochondrial protein synthesis to maintain ATP levels, potentially enhancing the activity of Mtif3. | ||||||
Oligomycin A | 579-13-5 | sc-201551 sc-201551A sc-201551B sc-201551C sc-201551D | 5 mg 25 mg 100 mg 500 mg 1 g | $175.00 $600.00 $1179.00 $5100.00 $9180.00 | 26 | |
Oligomycin inhibits ATP synthase, potentially increasing the demand for mitochondrial protein synthesis as the cell tries to compensate for reduced ATP production, which could enhance Mtif3 function. | ||||||