MS4A3 Activators
MS4A3 can engage a variety of signaling pathways to enhance its activity through phosphorylation. Forskolin serves as a direct stimulant of adenylyl cyclase, which catalyzes the conversion of ATP to cyclic AMP (cAMP). The increase in cAMP levels leads to the activation of protein kinase A (PKA), an enzyme responsible for phosphorylating a multitude of cellular proteins, including MS4A3. Similarly, Isoproterenol, a beta-adrenergic agonist, and Terbutaline, along with Salbutamol, which are beta2-adrenergic receptor agonists, trigger the same cascade through the beta-adrenergic receptor, culminating in the activation of PKA which can target MS4A3. Dopamine and Adenosine, engaging with D1-like and A2A receptors respectively, also elevate cAMP within the cell, further promoting PKA activity and the subsequent phosphorylation of MS4A3.
Prostaglandin E2 (PGE2) and Histamine, via their interaction with their respective G-protein-coupled receptors, also contribute to the rise in intracellular cAMP concentrations, leading to PKA-mediated phosphorylation processes that activate MS4A3. Epinephrine, acting on beta-adrenergic receptors, follows a similar mechanism, resulting in PKA activation. The phosphodiesterase inhibitors IBMX and Rolipram increase cAMP by preventing its breakdown, thus sustaining the activation signal for PKA, which in turn can phosphorylate MS4A3. Furthermore, BAY 60-6583, by selectively activating the adenosine A2B receptor, leads to the accumulation of cAMP and subsequent PKA activation, providing another route for the phosphorylation and activation of MS4A3. Each of these chemicals, through their unique interactions with cellular signaling pathways, ultimately converge on the activation of PKA, which then can phosphorylate and regulate the activity of MS4A3.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly activates adenylyl cyclase, increasing levels of cAMP. Elevated cAMP activates protein kinase A (PKA), which can lead to phosphorylation and activation of various proteins, potentially including MS4A3. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that increases intracellular cAMP by stimulating adenylyl cyclase through the beta-adrenergic receptor, thereby activating PKA, which may phosphorylate and activate MS4A3 as part of downstream signaling. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
Prostaglandin E2 (PGE2) interacts with its G-protein-coupled receptors to increase cAMP production, thus activating PKA, which could then phosphorylate substrates including MS4A3. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $92.00 $277.00 $969.00 | 7 | |
Histamine, through its action on H2 receptors, can increase cAMP levels and subsequently activate PKA, leading to the phosphorylation of various proteins, including possibly MS4A3. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine, when interacting with D1-like receptors, can increase cAMP levels in the cell, leading to activation of PKA, which may in turn phosphorylate and activate MS4A3. | ||||||
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $33.00 $47.00 $294.00 $561.00 $1020.00 $2550.00 $4590.00 | 1 | |
Adenosine, through the A2A receptor, increases intracellular cAMP and activates PKA, which might activate MS4A3 through phosphorylation. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Epinephrine, acting on beta-adrenergic receptors, increases cAMP and activates PKA, which is known to phosphorylate various proteins and could include MS4A3 in its range of substrates. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
3-Isobutyl-1-methylxanthine (IBMX) indirectly increases cAMP levels by inhibiting phosphodiesterases that break down cAMP, thereby promoting activation of PKA, which could lead to the activation of MS4A3. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram inhibits phosphodiesterase-4, leading to increased cAMP levels and subsequent activation of PKA. PKA may subsequently phosphorylate and activate MS4A3. | ||||||
Terbutaline Hemisulfate | 23031-32-5 | sc-204911 sc-204911A | 1 g 5 g | $90.00 $371.00 | 2 | |
Terbutaline is a beta2-adrenergic receptor agonist which increases cAMP in cells, thereby leading to PKA activation. PKA could phosphorylate and activate MS4A3. | ||||||