MS4A12 Inhibitors
MS4A12 Inhibitors encompass a range of chemical compounds that indirectly impact the activity of the MS4A12 protein by targeting signaling pathways and cellular processes with which MS4A12 is associated. Src familykinase inhibitors like PP2 could potentially lessen MS4A12 activity by disrupting the phosphorylation state of the protein, which is often a prerequisite for its function. Similarly, PI3K inhibitors such as LY294002 and Wortmannin could indirectly lead to decreased MS4A12 activity by impacting the PI3K/AKT pathway, which is integral to cell survival and receptor trafficking. As AKT phosphorylation is reduced, the cellular processes that maintain the localization and expression of MS4A12 at the cell surface may be compromised. Furthermore, the inhibition of PLC by compounds like U73122 could result in reduced downstream signaling through PKC, which is known to influence the function of various proteins, possibly including MS4A12, through phosphorylation events.
The functional mechanisms of MS4A12 inhibitors extend to other kinase pathways, such as the MAPK pathway, which can be interfered with by MEK inhibitors like PD98059 and p38 MAPK inhibitors such as SB203580. The MAPK/ERK and p38 MAPK pathways are critical for the phosphorylation and regulation of many cellular proteins, and their inhibition could decrease MS4A12 activity. Additionally, JNK inhibitors like SP600125 may lead to decreased MS4A12 activity by altering stress response signaling. The influence of mTOR signaling on protein activity is targeted by mTOR inhibitors such as Rapamycin, which can lead to decreased MS4A12 activity by affecting the cell's metabolic state. Lastly, EGFR inhibitors like Gefitinib disrupt EGFR signaling, which could downregulate MS4A12 by reducing the activity of pathways that would normally upregulate or maintain MS4A12 activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 is an Src family kinase inhibitor that obstructs Src family kinases. Src family kinases are involved in the regulation of receptor tyrosine kinase signaling, which can influence the activity of membrane proteins such as MS4A12 by altering their phosphorylation state. Therefore, inhibition of Src kinases by PP2 can lead to reduced MS4A12 activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that impedes the PI3K/AKT pathway, crucial for cell survival and proliferation. By inhibiting PI3K, LY294002 decreases AKT phosphorylation, which is important for the regulation of membrane protein trafficking and function, potentially leading to decreased MS4A12 activity due to impaired localization or expression on the cell surface. | ||||||
Chelerythrine | 34316-15-9 | sc-507380 | 100 mg | $540.00 | ||
Chelerythrine is a PKC inhibitor that can suppress the activity of protein kinase C isoforms. Given that PKC modulates the function of various proteins through phosphorylation, the use of chelerythrine could inhibit the phosphorylation-dependent regulation of MS4A12, leading to decreased activity. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
Bisindolylmaleimide I is another PKC inhibitor known to specifically inhibit PKC isoforms. By blocking PKC activity, Bisindolylmaleimide I could diminish the phosphorylation and regulation of MS4A12, leading to a decrease in its activity. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $103.00 $293.00 $465.00 | 15 | |
Go6983 is a potent inhibitor of several PKC isoforms. Inhibition of PKC by Go6983 can lead to reduced phosphorylation of proteins that are regulated by PKC-dependent signaling pathways, including MS4A12, which in turn could lead to diminished MS4A12 activity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a MEK inhibitor that interferes with the MAPK/ERK pathway. Since ERK is involved in the regulation of various cellular functions including protein phosphorylation, PD98059 can inhibit the phosphorylation of proteins downstream of ERK, which could include MS4A12, leading to its functional inhibition. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor that specifically inhibits p38 MAPK. Inhibition of p38 MAPK can alter cytokine production and stress response signaling, potentially affecting the activity of proteins like MS4A12 that may be modulated by these pathways. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK), which impacts the JNK signaling pathway involved in stress responses, apoptosis, and cytokine production. Inhibition of JNK signaling could influence the activity of proteins involved in these processes, leading to decreased activity of MS4A12. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent and irreversible inhibitor of PI3K. By blocking PI3K activity, wortmannin can reduce AKT signaling, which can have downstream effects on the regulation of proteins controlled by AKT, potentially leading to decreased MS4A12 activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor that attenuates mTOR signaling, which affects cell growth and metabolism. Downregulation of mTOR signaling can lead to reduced activity of proteins sensitive to the metabolic state of the cell, which could include MS4A12. | ||||||