MS4A12 Activators
MS4A12 induce a cascade of intracellular events that result in the activation of this protein. Forskolin directly stimulates adenylyl cyclase, thereby increasing cyclic AMP (cAMP) levels within the cell. The elevation of cAMP serves as a second messenger to activate protein kinase A (PKA), which can then target proteins such as MS4A12 for phosphorylation. Isoproterenol, functioning as a beta-adrenergic agonist, similarly promotes the activation of adenylyl cyclase through its interaction with G protein-coupled receptors. The consequent rise in cAMP levels leads to the activation of PKA, which in turn can phosphorylate MS4A12. Another chemical, prostaglandin E2 (PGE2), binds to its respective G protein-coupled receptors to activate adenylyl cyclase, resulting in increased cAMP and subsequent PKA-mediated phosphorylation of MS4A12.
3-Isobutyl-1-methylxanthine (IBMX), an inhibitor of phosphodiesterases, prevents the degradation of cAMP, thereby sustaining PKA activity and the potential for phosphorylation of MS4A12. Histamine engages with H2 receptors, which are linked to adenylyl cyclase, thereby raising cAMP levels and activating PKA, which can phosphorylate MS4A12. Epinephrine and dopamine, through their interactions with beta-adrenergic and D1-like receptors, respectively, also promote the accumulation of cAMP and activate PKA, leading to the phosphorylation of MS4A12. Adenosine works through A2 receptors to boost cAMP levels and activate PKA, which may phosphorylate MS4A12. In a similar vein, Rolipram, Salbutamol, and Terbutaline, by inhibiting phosphodiesterase or acting as beta2-adrenergic receptor agonists, induce an increase in cAMP, thereby facilitating PKA activation and subsequent phosphorylation of MS4A12. Cholera toxin, through its irreversible activation of the Gs alpha subunit, causes a continuous increase in cAMP, leading to persistent PKA activity and the potential for ongoing phosphorylation of MS4A12.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that stimulates adenylyl cyclase through G protein-coupled receptor signaling, increasing intracellular cAMP levels. The subsequent activation of PKA can lead to the phosphorylation and functional activation of proteins like MS4A12. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
Prostaglandin E2 (PGE2) binds to its G protein-coupled receptors, leading to the activation of adenylyl cyclase and an increase in cAMP. This elevation of cAMP can activate PKA, which could phosphorylate and thereby functionally activate MS4A12. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
3-Isobutyl-1-methylxanthine (IBMX) is a non-specific inhibitor of phosphodiesterases, which prevents the breakdown of cAMP. The resulting accumulation of cAMP can activate PKA, which may then phosphorylate and activate MS4A12. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $94.00 $283.00 $988.00 | 7 | |
Histamine can bind to H2 receptors, which are coupled to adenylyl cyclase via Gs proteins, leading to increased cAMP levels. The activation of PKA by cAMP may result in phosphorylation and activation of MS4A12. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine binds to beta-adrenergic receptors, stimulating adenylyl cyclase and increasing cAMP levels. The cAMP acts on PKA, which could phosphorylate and activate MS4A12 as part of its downstream effects. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine can interact with D1-like receptors that are coupled to adenylyl cyclase, elevating cAMP levels. This increase in cAMP may lead to the activation of PKA, which could phosphorylate and activate MS4A12. | ||||||
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $34.00 $48.00 $300.00 $572.00 $1040.00 $2601.00 $4682.00 | 1 | |
Adenosine can activate A2 receptors, which are linked to adenylyl cyclase activation and an increase in cAMP. The resulting activation of PKA could potentially lead to the phosphorylation and activation of MS4A12. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram is a selective inhibitor of phosphodiesterase 4, leading to increased cAMP levels. Elevated cAMP activates PKA, which may phosphorylate and thereby activate MS4A12. | ||||||
Salbutamol | 18559-94-9 | sc-253527 sc-253527A | 25 mg 50 mg | $94.00 $141.00 | ||
Salbutamol is a selective beta2-adrenergic receptor agonist that increases cAMP levels by activating adenylyl cyclase. The resulting PKA activation may lead to phosphorylation and activation of MS4A12. | ||||||