MRS2L Activators
The first category of MRS2L activators includes molecules that modulate cAMP levels or PKA activity, such as Forskolin and 8-Br-cAMP. By increasing cAMP levels or directly affecting PKA, these compounds can have an indirect effect on MRS2L, particularly through phosphorylation events that could modulate its activity or expression. For example, Forskolin's role in elevating cAMP levels leads to PKA activation, which can phosphorylate various substrates that in turn affect ion channels like MRS2L. 8-Br-cAMP serves as a cell-permeable analog of cAMP and can similarly activate PKA, affecting the same pathway.
Another class focuses on calcium-dependent signaling. Compounds like Ionomycin and Thapsigargin elevate intracellular calcium levels, thereby influencing MRS2L through calcium-dependent mechanisms. Specifically, Ionomycin works by forming complexes with calcium ions, effectively shuttling them across biological membranes, which can alter calcium-dependent signaling affecting MRS2L. Thapsigargin inhibits the ER Ca2+ ATPase, thus raising intracellular Ca2+ levels, which may also indirectly affect MRS2L.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Increases cAMP levels, potentially influencing ion channels, including MRS2L, via PKA phosphorylation. | ||||||
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $108.00 $169.00 $295.00 $561.00 $835.00 | 2 | |
A cell-permeable cAMP analog that can affect PKA, thereby possibly affecting MRS2L. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Increases intracellular Ca2+ levels, which can indirectly affect MRS2L through calcium-dependent signaling. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Elevates intracellular Ca2+ by inhibiting the ER Ca2+ ATPase, which may indirectly affect MRS2L. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Acts as a broad-spectrum tyrosine kinase inhibitor, thereby potentially affecting MRS2L through interconnected pathways. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Activates protein kinase C, which could phosphorylate substrates that influence MRS2L activity. | ||||||
Baicalein | 491-67-8 | sc-200494 sc-200494A sc-200494B sc-200494C | 10 mg 100 mg 500 mg 1 g | $32.00 $42.00 $162.00 $292.00 | 12 | |
Inhibits certain ion channels, potentially affecting the cellular environment in which MRS2L functions. | ||||||
Quinidine | 56-54-2 | sc-212614 | 10 g | $104.00 | 3 | |
Blocks various ion channels, which may alter the cellular context for MRS2L function. | ||||||
A-769662 | 844499-71-4 | sc-203790 sc-203790A sc-203790B sc-203790C sc-203790D | 10 mg 50 mg 100 mg 500 mg 1 g | $184.00 $741.00 $1076.00 $3417.00 $5304.00 | 23 | |
Activates AMPK, which can influence cellular ion balance, thereby affecting MRS2L indirectly. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Another cell-permeable cAMP analog that can activate PKA, potentially affecting MRS2L. | ||||||