MRP-S17 Activators
MRP-S17 Activators encompass a variety of chemical compounds that facilitate the upregulation and enhancement of the MRP-S17 protein's functional activity within the cellular environment. Forskolin, a potent activator of adenylyl cyclase, raises cAMP levels, leading to the activation of PKA, which can phosphorylate proteins including those associated with MRP-S17's transport functions, thus promoting its activity. Similarly, Curcumin and Resveratrol exert their effects by modulating NF-κB and activating SIRT1, respectively, which can influence the cellular redox state and metabolism, potentially enhancing the expression and function of MRP-S17. Compounds like Sulforaphane, Oltipraz, and tert-butylhydroquinone specifically activate the Nrf2 pathway, a critical regulator of the cellular defense mechanism, resulting in increased expression and activity of MRP-S17, which contributes to the efflux of oxidative stress-related toxic compounds. Indole-3-carbinol also enhances the detoxification process via Nrf2 pathway modulation, further facilitating MRP-S17's role in exporting carcinogens and toxins.
Additional activators like Quercetin and Epigallocatechin gallate (EGCG) indirectly enhance MRP-S17's activity by modulating pathways associated with inflammation and the cellular stress response, providing a protective effect against oxidative damage. Zinc pyrithione, by activating MTF-1, influences MRP-S17's potential in metal ion transport, while Dimethyl fumarate enhances cellular defense mechanisms against oxidative stress by also activating the Nrf2 pathway, boosting MRP-S17's role in effluxing electrophilic compounds. These diverse molecules, though varied in their primary biological targets, converge on pathways that ultimately enhance the activity of MRP-S17, ensuring the efficient functioning of the protein in its role as a cellular defender and transporter, without the need for direct activation or increased expression.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is a diterpenoid that activates adenylyl cyclase, leading to an increase in cyclic AMP (cAMP) levels. Elevated cAMP activates protein kinase A (PKA), which can phosphorylate various proteins including those associated with the transport functions of MRP-S17, thereby enhancing its transporter activity. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane is an isothiocyanate derived from cruciferous vegetables that can activate the Nrf2 pathway, a regulator of cellular resistance to oxidants. Nrf2 activation upregulates the expression of various antioxidant proteins, including MRP-S17, which plays a role in the cellular defense mechanism by exporting oxidative stress-related toxic compounds out of the cell. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin is a polyphenol compound with anti-inflammatory and antioxidant properties. It can modulate the activity of NF-κB, a transcription factor that regulates the expression of genes involved in inflammation and survival. By inhibiting NF-κB, curcumin can alter the cellular redox state, potentially affecting the expression and activity of MRP-S17 as part of the cell's response to oxidative stress. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol is a natural phenol found in grapes and berries. It has been shown to activate SIRT1, a NAD+-dependent deacetylase, which can influence cellular metabolism and survival pathways. Activation of SIRT1 may lead to the deacetylation of proteins that regulate MRP-S17 function, potentially increasing its transporter activity. | ||||||
Oltipraz | 64224-21-1 | sc-205777 sc-205777A | 500 mg 1 g | $286.00 $622.00 | ||
Oltipraz is a dithiolethione derivative that activates the Nrf2 pathway, leading to the induction of phase II detoxifying enzymes and efflux transporters such as MRP-S17. By activating Nrf2, oltipraz enhances the expression and function of MRP-S17, promoting the efflux of xenobiotics and contributing to cellular defense mechanisms. | ||||||
t-Butylhydroquinone | 1948-33-0 | sc-202825 | 10 g | $66.00 | 4 | |
Tert-butylhydroquinone (tBHQ) is an aromatic organic compound that can induce the Nrf2-mediated antioxidant response. By activating Nrf2, tBHQ leads to the upregulation of MRP-S17, enhancing its role in the cellular detoxification process by exporting harmful compounds out of the cell. | ||||||
Indole-3-carbinol | 700-06-1 | sc-202662 sc-202662A sc-202662B sc-202662C sc-202662D | 1 g 5 g 100 g 250 g 1 kg | $38.00 $60.00 $143.00 $306.00 $1012.00 | 5 | |
Indole-3-carbinol is a compound found in cruciferous vegetables that modulates several detoxification enzymes. It can influence the Nrf2 pathway, resulting in the upregulation of MRP-S17 and the enhancement of its detoxifying activity in the cell by facilitating the export of carcinogens and other toxic compounds. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin is a flavonoid with antioxidant properties that can modulate signaling pathways involved in inflammation and oxidative stress. By affecting these pathways, quercetin may indirectly enhance the activity of MRP-S17, contributing to the cellular protective mechanisms against oxidative damage. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin gallate (EGCG) is the most abundant catechin in green tea with antioxidant properties. It can modulate several cellular pathways, including those related to the cellular stress response. Through these pathways, EGCG may contribute to the upregulation and enhanced activity of MRP-S17, aiding in the removal of toxins and protecting cells from oxidative stress. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc pyrithione is a coordination complex of zinc that is known to inhibit the division of fungal cells. It has also been shown to activate metal-responsive transcription factor 1 (MTF-1), which can influence the expression of various metallothioneins and proteins associated with metal ion homeostasis, including MRP-S17, potentially enhancing its metal ion transport activity. | ||||||