Date published: 2026-5-15

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MRP-S17 Inhibitors

MRP-S17 inhibitors belong to a class of chemical compounds specifically designed to target and inhibit the activity of the MRP-S17 protein. The MRP-S17 protein, also known as Multidrug Resistance-Associated Protein S17, is a member of the ATP-binding cassette (ABC) transporter superfamily. This superfamily of membrane proteins plays a crucial role in cellular transport processes by utilizing the energy found in ATP hydrolysis to actively pump various substrates across cell membranes. MRP-S17, in particular, has been identified as a transporter associated with multidrug resistance in certain cells, contributing to the efflux of diverse molecules from the intracellular environment. The development of MRP-S17 inhibitors stems from the need to modulate the function of this transporter. Researchers have focused on understanding the structural and biochemical characteristics of MRP-S17 to design molecules that can selectively bind to and inhibit its activity. The inhibition of MRP-S17 aims to interfere with the efflux of drugs or other substances. The structural diversity of MRP-S17 inhibitors allows for the exploration of various chemical scaffolds and modifications to optimize their binding affinity and selectivity.

Items 1 to 10 of 11 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Rapamycin

53123-88-9sc-3504
sc-3504A
sc-3504B
1 mg
5 mg
25 mg
$63.00
$158.00
$326.00
233
(4)

Rapamycin is an mTOR inhibitor that can reduce the activity of proteins involved in mTOR signaling. Given that mTOR can regulate protein synthesis and cell growth, inhibiting this pathway can lead to a reduction in the functional activity of MRP-S17 if it is implicated in these cellular processes.

LY 294002

154447-36-6sc-201426
sc-201426A
5 mg
25 mg
$123.00
$400.00
148
(1)

LY294002 is a PI3K inhibitor that suppresses the PI3K/Akt/mTOR pathway. By inhibiting this upstream signaling, LY294002 can indirectly decrease the activity of MRP-S17 if it is downstream of this pathway.

PD 98059

167869-21-8sc-3532
sc-3532A
1 mg
5 mg
$40.00
$92.00
212
(2)

WZB117 inhibits glucose transporter 1 (GLUT1), which could reduce the energy supply necessary for the proper function of MRP-S17 if it relies on high levels of glycolysis for its activity.

Brefeldin A

20350-15-6sc-200861C
sc-200861
sc-200861A
sc-200861B
1 mg
5 mg
25 mg
100 mg
$31.00
$53.00
$124.00
$374.00
25
(3)

Brefeldin A disrupts protein trafficking by inhibiting ADP-ribosylation factor, which could affect the localization and function of MRP-S17 if it is dependent on vesicular transport.

U-0126

109511-58-2sc-222395
sc-222395A
1 mg
5 mg
$64.00
$246.00
136
(2)

U0126 is an inhibitor of MEK, which blocks the ERK/MAPK pathway. If MRP-S17 activity is modulated by MAPK signaling, U0126 could indirectly decrease its functional activity.

SB 203580

152121-47-6sc-3533
sc-3533A
1 mg
5 mg
$90.00
$349.00
284
(5)

SB203580 is a p38 MAPK inhibitor. Inhibition of p38 MAPK can suppress inflammatory responses and could indirectly affect MRP-S17 activity if it plays a role in inflammation or stress response pathways.

NSC 23766

733767-34-5sc-204823
sc-204823A
10 mg
50 mg
$151.00
$609.00
75
(4)

NSC 23766 inhibits Rac1, which is involved in actin cytoskeleton organization. Impairing actin polymerization might affect the cellular localization or function of MRP-S17 if it interacts with the cytoskeleton.

SP600125

129-56-6sc-200635
sc-200635A
10 mg
50 mg
$40.00
$150.00
257
(3)

SP600125 inhibits JNK, which is involved in stress signaling pathways. If MRP-S17 is implicated in these pathways, JNK inhibition could lead to a decrease in its activity.

Wortmannin

19545-26-7sc-3505
sc-3505A
sc-3505B
1 mg
5 mg
20 mg
$67.00
$223.00
$425.00
97
(3)

Wortmannin is a potent PI3K inhibitor, leading to the inhibition of Akt phosphorylation. If MRP-S17 activity is regulated by the PI3K/Akt pathway, wortmannin could indirectly decrease its activity.

Cycloheximide

66-81-9sc-3508B
sc-3508
sc-3508A
100 mg
1 g
5 g
$41.00
$84.00
$275.00
127
(6)

Cycloheximide inhibits protein synthesis by interfering with the translocation step in protein elongation. This can lead to a general decrease in protein levels, potentially affecting the expression and function of MRP-S17.