MRP-S17 Inhibitors

MRP-S17 inhibitors belong to a class of chemical compounds specifically designed to target and inhibit the activity of the MRP-S17 protein. The MRP-S17 protein, also known as Multidrug Resistance-Associated Protein S17, is a member of the ATP-binding cassette (ABC) transporter superfamily. This superfamily of membrane proteins plays a crucial role in cellular transport processes by utilizing the energy found in ATP hydrolysis to actively pump various substrates across cell membranes. MRP-S17, in particular, has been identified as a transporter associated with multidrug resistance in certain cells, contributing to the efflux of diverse molecules from the intracellular environment. The development of MRP-S17 inhibitors stems from the need to modulate the function of this transporter. Researchers have focused on understanding the structural and biochemical characteristics of MRP-S17 to design molecules that can selectively bind to and inhibit its activity. The inhibition of MRP-S17 aims to interfere with the efflux of drugs or other substances. The structural diversity of MRP-S17 inhibitors allows for the exploration of various chemical scaffolds and modifications to optimize their binding affinity and selectivity.