MRP-S11 Activators
MRP-S11 activators are specialized molecules engineered to modulate the activity of the MRP-S11 protein, which is one of the many proteins involved in cellular transport mechanisms. These activators interact with their target protein at a molecular level, often by binding to specific sites on the protein structure, which can result in a change in the protein's conformation and subsequently affect its function. The design of these activators requires a comprehensive understanding of the protein's three-dimensional shape and the various forces that govern ligand-protein interactions. This is a highly detailed field of study involving the principles of organic chemistry, protein biochemistry, and molecular biology. Researchers employ an array of techniques, including x-ray crystallography and nuclear magnetic resonance (NMR) spectroscopy, to obtain detailed images of the protein in question, which then informs the design of molecules that can interact with it effectively.
The process of developing these activators encompasses not just the synthesis of potential compounds but also rigorous testing to determine their efficacy at modulating the MRP-S11 protein's activity. This involves various in vitro experiments, which may include assays to measure the binding affinity and kinetic parameters of these interactions. MRP-S11 activators must demonstrate a high degree of specificity to ensure that they interact primarily with the intended protein, thereby reducing the likelihood of affecting other proteins and cellular processes. Advances in computational chemistry, such as molecular modeling and simulations, play a critical role in predicting how these activators will interact with the MRP-S11 protein before they are synthesized. The field relies heavily on iterative design, where initial hypotheses are tested and refined based on empirical data, driving the synthesis of new compounds with improved properties. Overall, MRP-S11 activators are a product of intricate scientific inquiry, designed to interact with complex biological systems at a fundamental level.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is a labdane diterpenoid that activates adenylyl cyclase, leading to an increase in cyclic AMP (cAMP) levels. Elevated cAMP activates PKA, which can phosphorylate and hence enhance the activity of MRP-S11 by improving its transport function. | ||||||
(±)-S-Nitroso-N-acetylpenicillamine | 79032-48-7 | sc-200319B sc-200319 sc-200319A | 10 mg 20 mg 100 mg | $73.00 $112.00 $367.00 | 18 | |
Nitric oxide donors release nitric oxide (NO), which can stimulate guanylyl cyclase to increase cGMP levels. This can indirectly enhance the function of MRP-S11 by modulating signaling pathways that regulate cellular efflux mechanisms. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a catechin found in green tea with antioxidant properties. It can modulate multiple signaling pathways, potentially enhancing MRP-S11 activity by altering redox status and thus affecting the protein's regulatory control over efflux of oxidative stress-related compounds. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin is a natural phenol from turmeric with various biological activities. It can modulate the activity of NF-κB and other transcription factors, potentially increasing the functional activity of MRP-S11 in cellular defense mechanisms. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol is a polyphenol that can activate SIRT1, an NAD-dependent deacetylase. Activation of SIRT1 can enhance MRP-S11 activity by modulating cellular stress response pathways in which MRP-S11 is involved. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane is an isothiocyanate from cruciferous vegetables that can activate Nrf2, a transcription factor that regulates antioxidant response elements. This activation can enhance MRP-S11 function in detoxification pathways. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc is a trace element that can stabilize the structure of proteins and enzymes. The binding of zinc can enhance the activity of MRP-S11 by improving its structural integrity, resulting in better transport efficiency. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin is a flavonoid with antioxidant properties that can modulate various signaling pathways, including those involving kinases and phosphatases. These actions can enhance MRP-S11 activity by affecting its role in cellular transport processes. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $68.00 $120.00 $208.00 $373.00 $702.00 | 3 | |
Alpha-Lipoic Acid is an organosulfur compound derived from caprylic acid. It can enhance the activity of MRP-S11 through its involvement in cellular antioxidant systems, potentially affecting MRP-S11's role in the efflux of oxidized molecules. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
Capsaicin is the active component of chili peppers that can activate TRPV1, a receptor involved in pain and heat sensation. Activation of TRPV1 can lead to an increase in intracellular calcium, potentially enhancing MRP-S11 activity by modulating calcium-dependent signaling pathways. | ||||||