MRP-L20 Activators
MRP-L20 activators constitute a class of chemical compounds designed to interact with and modulate the activity of the MRP-L20 protein. MRP-L20, also known as Mitochondrial Ribosomal Protein L20, is a component of the large subunit of the mitochondrial ribosome, which is responsible for synthesizing proteins within the mitochondria. These ribosomes play a crucial role in translating messenger RNA (mRNA) into functional proteins that are essential for various cellular processes, including energy production through oxidative phosphorylation. While the specific functions of MRP-L20 are still being elucidated, it is believed to participate in the assembly and stability of the mitochondrial ribosome, as well as potentially contributing to the regulation of mitochondrial protein synthesis. The term activators suggests that these compounds engage with MRP-L20 to modulate its activity, potentially leading to downstream effects on mitochondrial protein synthesis and cellular physiology.
Research into MRP-L20 activators involves investigating the molecular mechanisms underlying their interaction with the MRP-L20 protein and how this interaction influences mitochondrial protein synthesis and function. Understanding the pharmacological properties of these compounds is crucial for deciphering how they impact MRP-L20 activity and potentially affect mitochondrial ribosome assembly, protein synthesis, and overall mitochondrial function. By unraveling the biological functions and regulatory mechanisms of MRP-L20, researchers aim to deepen our understanding of mitochondrial biology and may uncover novel insights into the molecular pathways underlying mitochondrial protein synthesis and cellular metabolism. Continued investigation into MRP-L20 activators holds promise for advancing our knowledge of cellular physiology and may provide insights into new strategies for manipulating mitochondrial function in experimental contexts.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
AICAR mimics energy depletion, activating AMPK, which can lead to mitochondrial biogenesis and potentially upregulate MRP-L20 as part of this process. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
As a sirtuin activator, resveratrol can promote mitochondrial biogenesis and function, possibly increasing the demand for mitochondrial ribosomal proteins like MRP-L20. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $77.00 | 2 | |
Often used for its effects on glucose metabolism, metformin can activate AMPK, potentially enhancing mitochondrial biogenesis and the expression of components like MRP-L20. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Involved in cell differentiation and metabolism, retinoic acid might influence mitochondrial biogenesis and, consequently, the expression of mitochondrial proteins including MRP-L20. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $54.00 $123.00 | 13 | |
PPAR agonists can promote mitochondrial biogenesis and function, potentially increasing the expression of mitochondrial ribosomal proteins such as MRP-L20. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $56.00 $595.00 $173.00 | ||
Spermidine can induce autophagy and mitochondrial renewal, potentially leading to increased expression of mitochondrial components, including MRP-L20. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
By inhibiting mTOR, rapamycin can induce autophagy, including mitophagy, potentially leading to a compensatory increase in mitochondrial biogenesis and MRP-L20 expression. | ||||||
3-Hydroxybutyric acid | 300-85-6 | sc-231749 sc-231749A sc-231749B | 1 g 5 g 25 g | $70.00 $120.00 $440.00 | ||
As a ketone body produced during fasting or ketogenic diets, beta-hydroxybutyrate can signal energy stress, potentially enhancing mitochondrial biogenesis and MRP-L20 expression. | ||||||
Antimycin A | 1397-94-0 | sc-202467 sc-202467A sc-202467B sc-202467C | 5 mg 10 mg 1 g 3 g | $54.00 $62.00 $1642.00 $4600.00 | 51 | |
By inhibiting complex III of the electron transport chain, Antimycin A induces mitochondrial stress, possibly leading to adaptive increases in mitochondrial ribosomal proteins like MRP-L20. | ||||||
Carbonyl Cyanide m-Chlorophenylhydrazone | 555-60-2 | sc-202984A sc-202984 sc-202984B | 100 mg 250 mg 500 mg | $75.00 $150.00 $235.00 | 8 | |
As a mitochondrial uncoupler, CCCP disrupts mitochondrial membrane potential, potentially inducing a compensatory response that includes upregulation of MRP-L20. | ||||||