MPV17 Inhibitors

Chemical inhibitors of MPV17 can disrupt the protein's function through several mechanisms that target mitochondrial integrity and energy metabolism. 2-Aminoethyl diphenylborinate, for instance, inhibits MPV17 by disturbing mitochondrial membrane potential and calcium homeostasis, crucial for the protein's localization and function within the mitochondria. Carboxin further inhibits MPV17 by impairing mitochondrial respiratory chain complex II, which is intimately connected to the protein's role in mitochondrial DNA maintenance. Decylubiquinone serves as a ubiquinone analog, disrupting electron transport and, consequently, the mitochondrial function that MPV17 supports. Thenoyltrifluoroacetone exerts its inhibitory effect by chelating metal ions critical for the functioning of respiratory complexes that MPV17 relies on, thereby impeding the protein's ability to maintain mitochondrial integrity.

Oligomycin A specifically targets mitochondrial ATP synthase, thereby reducing the mitochondrial membrane potential that is essential for MPV17's function. Antimycin A binds to cytochrome b within the electron transport chain, blocking electron transport and affecting the mitochondrial integrity that MPV17 helps maintain. Atrazine disrupts complex III of the mitochondrial electron transport chain, leading to mitochondrial dysfunction and an indirect inhibition of MPV17. Rotenone directly inhibits mitochondrial complex I, decreasing the mitochondrial membrane potential necessary for MPV17's role. Sodium azide targets cytochrome c oxidase, a component of the electron transport chain, crucial for the mitochondrial function supported by MPV17. CCCP uncouples oxidative phosphorylation, leading to the collapse of the proton gradient and mitochondrial membrane potential, which in turn affects MPV17. Paraquat induces oxidative stress, damaging mitochondrial DNA and thereby inhibiting the protective role of MPV17. Lastly, Mitoquinone mesylate targets mitochondria to modulate their redox status, which can lead to oxidative damage and thus inhibit the mitochondrial protective role of MPV17.