MORN4 Activators
MORN4 activators as a chemical class are not unified by a common mode of direct action on the protein but rather by their influence on cellular lipid signaling pathways and membrane dynamics that could indirectly modulate the activity of MORN4. The interaction between MORN4 and the cellular membrane is pivotal, as MORN domains are known to have phospholipid-binding properties. By altering the lipid composition or signaling within the cell membrane, these compounds can create a biochemical context that is conducive to modulating the localization, stability, or interaction profile of MORN4 within the cellular environment. For instance, changes in the levels of phosphatidylinositol or ceramide could reconfigure the lipid landscape, affecting the binding and function of MORN4.
Furthermore, the regulatory capacity of these compounds extends to the modulation of signaling cascades and cellular processes that involve lipids, such as apoptosis, differentiation, and migration. By impacting these broader cellular events, the compounds could create secondary effects that influence the function of MORN4. For example, fingolimod's modulation of sphingosine-1-phosphate receptors alters lymphocyte egress, which may indirectly impact the spatial distribution and function of proteins associated with these cells, potentially including MORN4. Additionally, alterations in cholesterol levels by simvastatin can modify membrane fluidity, thus influencing the interactions of MORN4 with other membrane-bound molecules.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
L-α-Phosphatidylinositol sodium salt | 383907-36-6 | sc-221821 | 10 mg | $400.00 | 1 | |
Phosphatidylinositol is a phospholipid that forms part of the cell membrane and can serve as a precursor for various signaling molecules. Altered levels of phosphatidylinositol can modify MORN4 interactions with the membrane, potentially modulating its activity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
Lysophosphatidic acid (LPA) is a signaling molecule that activates G-protein coupled receptors, which could lead to downstream signaling events affecting proteins with MORN motifs like MORN4. | ||||||
Fingolimod | 162359-55-9 | sc-507334 | 10 mg | $160.00 | ||
Fingolimod is a sphingosine-1-phosphate receptor modulator that alters lymphocyte migration; it may influence MORN4 by altering the lipid signaling environment. | ||||||
D-erythro-Sphingosine | 123-78-4 | sc-3546 sc-3546A sc-3546B sc-3546C sc-3546D sc-3546E | 10 mg 25 mg 100 mg 1 g 5 g 10 g | $88.00 $190.00 $500.00 $2400.00 $9200.00 $15000.00 | 2 | |
Sphingosine serves as a backbone for sphingolipids and can modulate cell signaling pathways; changes in sphingolipid metabolism could influence MORN4 activity. | ||||||
C-8 Ceramide | 74713-59-0 | sc-205233 sc-205233A sc-205233B | 1 mg 5 mg 25 mg | $19.00 $63.00 $228.00 | 1 | |
Ceramide is involved in cellular signaling pathways including apoptosis and differentiation; fluctuations in ceramide levels can affect membrane-associated proteins like MORN4. | ||||||
Myriocin (ISP-1) | 35891-70-4 | sc-201397 | 10 mg | $106.00 | 8 | |
Myriocin is a potent inhibitor of serine palmitoyltransferase, the initial step in sphingolipid synthesis; it can indirectly influence proteins that interact with sphingolipids or related metabolites, potentially including MORN4. | ||||||
Propranolol | 525-66-6 | sc-507425 | 100 mg | $180.00 | ||
Propranolol is a beta-blocker that can affect phospholipid metabolism; it might indirectly modulate the function of proteins associated with the membrane, such as MORN4. | ||||||
Simvastatin | 79902-63-9 | sc-200829 sc-200829A sc-200829B sc-200829C | 50 mg 250 mg 1 g 5 g | $30.00 $87.00 $132.00 $434.00 | 13 | |
Simvastatin, a statin, inhibits HMG-CoA reductase leading to altered cholesterol synthesis, which may indirectly affect MORN4 by changing the lipid composition of membranes. | ||||||
Miltefosine | 58066-85-6 | sc-203135 | 50 mg | $79.00 | 8 | |
Miltefosine interferes with lipid metabolism and signaling, which may affect the localization and function of lipid-binding proteins like MORN4. | ||||||
Perifosine | 157716-52-4 | sc-364571 sc-364571A | 5 mg 10 mg | $184.00 $321.00 | 1 | |
Perifosine is an alkylphospholipid that acts on signal transduction pathways and membrane lipid composition, potentially impacting MORN4 function. | ||||||