Mlx Inhibitors
Mlx inhibitors, short for Max-like protein X inhibitors, represent a class of chemical compounds that play a crucial role in the regulation of cellular processes related to metabolism and energy homeostasis. The Max-like protein X, or Mlx, is a transcription factor that forms complexes with other proteins, such as Mlx interacting protein (Mlxip) or MondoA, to control the expression of genes involved in glucose metabolism, lipid metabolism, and other cellular activities. Mlx inhibitors are designed to target and modulate the activity of Mlx and its associated proteins, thereby influencing various metabolic pathways.
These inhibitors typically function by disrupting the interaction between Mlx and its binding partners, them from binding to specific DNA sequences and regulating the expression of genes involved in glucose uptake, glycolysis, and lipogenesis. By interfering with these processes, Mlx inhibitors have the potential to impact cellular metabolism and energy balance, making them valuable tools in understanding the intricate regulatory mechanisms governing metabolic pathways.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
Triptolide inhibits the transcriptional activity of MLX by interfering with the assembly of the MLX transcriptional complex, leading to reduced expression of target genes. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane modulates the activity of MLX by inducing antioxidant response elements which can alter the transcriptional activity of MLX-related pathways. | ||||||
Wiskostatin | 253449-04-6 | sc-204399 sc-204399A sc-204399B sc-204399C | 1 mg 5 mg 25 mg 50 mg | $49.00 $124.00 $441.00 $828.00 | 4 | |
WZB117 interacts with the glucose transporter GLUT1, which may indirectly affect MLX activity by altering cellular glucose levels and metabolic status, potentially impacting MLX-dependent gene regulation. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein, an isoflavone, can act as a tyrosine kinase inhibitor, indirectly influencing MLX transcriptional activity by altering phosphorylation states of proteins within MLX-related signaling pathways. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is a MEK inhibitor that can indirectly affect MLX activity by altering the MAPK/ERK pathway, which can influence the transcriptional regulation by MLX. | ||||||
SN 38 | 86639-52-3 | sc-203697 sc-203697A sc-203697B | 10 mg 50 mg 500 mg | $119.00 $342.00 $883.00 | 19 | |
SN-38, the active metabolite of irinotecan, can indirectly affect MLX by inhibiting topoisomerase I, leading to DNA damage and potential disruption of MLX-mediated transcription. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol can modulate the activity of sirtuins and influence MLX protein function indirectly through alterations in cellular stress responses and metabolism. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Chloroquine can affect the lysosomal degradation pathways, which may indirectly affect the stability and function of the MLX protein. | ||||||
17-AAG | 75747-14-7 | sc-200641 sc-200641A | 1 mg 5 mg | $67.00 $156.00 | 16 | |
17-AAG, an HSP90 inhibitor, can lead to the destabilization and degradation of client proteins including those that interact with MLX, thereby potentially modulating MLX activity. | ||||||