Molecular structure of SN 38, CAS Number: 86639-52-3
SN 38 (CAS 86639-52-3)
See product citations (19)
Alternate Names:
SN 38 is also known as NK 012.
Application:
SN 38 is the active metabolite of the topoisomerase-I (topo-I) inhibitor Irinotecan (CPT-11), able to inhibit DNA topoisomerase I.
CAS Number:
86639-52-3
Purity:
≥98%
Molecular Weight:
392.41
Molecular Formula:
C22H20N2O5
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
SN 38 inhibits DNA and RNA synthesis (IC50 values are 0.077 and 1.3 µM respectively) but does not affect protein synthesis. SN 38 displays potent antitumor activity against a range of human tumor cell lines (IC50 values are 3.3, 13, 19 and 22 nM for HCT-116, BEL-7402, HL60 and HELA cells respectively). SN 38 is anctive metabolite of CPT-11 that inhibits DNA topoisomerase I (IC50 values are 0.74 and 1.9 μM in P388 and Ehrlich cells respectively). During hydrolysis, SN 38 is formed when the carboxylesterases metabolize irinotecan through glucuronidation by UDP glucuronosyl transferase 1A1. Compared to irinotecan, SN 38 is a more potent topoisomerase I inhibitor, and more cytotoxic to HT-29 colon cancer cells.
SN 38 (CAS 86639-52-3) References
- Inhibition of SN-38 glucuronidation by gefitinib and its metabolite. | Li, W., et al. 2015. Cancer Chemother Pharmacol. 75: 1253-60. PMID: 25917289
- Preparation and Characterization of SN-38-Encapsulated Phytantriol Cubosomes Containing α-Monoglyceride Additives. | Ali, MA., et al. 2016. Chem Pharm Bull (Tokyo). 64: 577-84. PMID: 27250792
- Gene-by-Environment Interaction of Bcrp-/- and Methionine- and Choline-Deficient Diet-Induced Nonalcoholic Steatohepatitis Alters SN-38 Disposition. | Toth, EL., et al. 2018. Drug Metab Dispos. 46: 1478-1486. PMID: 30166404
- SN-38, the active metabolite of irinotecan, inhibits the acute inflammatory response by targeting toll-like receptor 4. | Wong, DVT., et al. 2019. Cancer Chemother Pharmacol. 84: 287-298. PMID: 31011814
- Antibody-drug conjugates targeting TROP-2 and incorporating SN-38: A case study of anti-TROP-2 sacituzumab govitecan. | Goldenberg, DM. and Sharkey, RM. 2019. MAbs. 11: 987-995. PMID: 31208270
- Uremic serum residue decreases SN-38 sensitivity through suppression of organic anion transporter polypeptide 2B1 in LS-180 colon cancer cells. | Ozawa, S., et al. 2019. Sci Rep. 9: 15464. PMID: 31664047
- PLX038: a PEGylated prodrug of SN-38 independent of UGT1A1 activity. | Fontaine, SD., et al. 2020. Cancer Chemother Pharmacol. 85: 225-229. PMID: 31707444
- In vitro metabolic biomodulation of irinotecan to increase potency and reduce dose-limiting toxicity by inhibition of SN-38 glucuronide formation. | Crane, RA., et al. 2022. Drug Metab Pers Ther. 37: 295-303. PMID: 35257538
- The semi-synthetic flavonoid 2',3',4'-trihydroxyflavone (2-D08) inhibits both SN-38- and cytokine-evoked increases in epithelial barrier permeability in an in vitro intestinal mucositis model. | Marsh, DT. and Smid, SD. 2022. Food Funct. 13: 11142-11152. PMID: 36205567
- SN-38 Sensitizes BRCA-Proficient Ovarian Cancers to PARP Inhibitors through Inhibiting Homologous Recombination Repair. | Lin, S., et al. 2022. Dis Markers. 2022: 7243146. PMID: 36267463
- SN-38, an active metabolite of irinotecan, enhances anti-PD-1 treatment efficacy in head and neck squamous cell carcinoma. | Lee, YM., et al. 2023. J Pathol. 259: 428-440. PMID: 36641765
- Preclinical evaluation of CPT-11 and its active metabolite SN-38. | Lavelle, F., et al. 1996. Semin Oncol. 23: 11-20. PMID: 8633248
- SN-38, a metabolite of the camptothecin derivative CPT-11, potentiates the cytotoxic effect of radiation in human colon adenocarcinoma cells grown as spheroids. | Omura, M., et al. 1997. Radiother Oncol. 43: 197-201. PMID: 9192967
Inhibitor of:
cathepsin 3, CCR-9, CHMP3, DDX54, DPH2, EWS, Fragilis, Histone cluster 1 H2AN, HIVEP3, hPMS1, Kinocilin, LOC100039946, MCCB, Mlx, OR7G3, p20-ARC, p68 RNA Helicase, Paip2, PLGLB1, Polyserase-3, POTE15, RBMY1E, Reg I, Rhox4a, Topo, Topo I, TPSD1, Vmn2r42, VN1R4, XRRA1, ZNF225, ZNF233, ZNF31, ZNF396, ZNF436, and ZNF507.Activator of:
4930547C10Rik, LRGUK, Synaptotagmin XVI, and XRCC4.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SN 38, 10 mg | sc-203697 | 10 mg | $119.00 | |||
SN 38, 50 mg | sc-203697A | 50 mg | $342.00 | |||
SN 38, 500 mg | sc-203697B | 500 mg | $883.00 |