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SN 38 (CAS 86639-52-3) - chemical structure image
Molecular structure of SN 38, CAS Number: 86639-52-3
SN 38 (CAS 86639-52-3) - chemical structure image
Molecular structure of SN 38, CAS Number: 86639-52-3
SN 38: sc-203697. Western blot analysis of p21 expression in untreated (A) and SN 38 treated (B) HCT 116 whole cell lysate
SN 38: sc-203697. Western blot analysis of p21 expression in untreated (A) and SN 38 treated (B) HCT 116 whole cell lysates. Note upregulation of p21 expression in lane B. Antibody tested: p21 (F-5): sc-6246.
SN 38: sc-203697. Western blot analysis of p53 expression in untreated (A) and SN 38 treated (B) HCT 116 whole cell lysate
SN 38: sc-203697. Western blot analysis of p53 expression in untreated (A) and SN 38 treated (B) HCT 116 whole cell lysates. Note upregulation of p53 expression in lane B. Antibody tested: p53 (DO-1): sc-126.
Molecular structure of SN 38, CAS Number: 86639-52-3

SN 38 (CAS 86639-52-3)

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Alternate Names:
SN 38 is also known as NK 012.
Application:
SN 38 is the active metabolite of the topoisomerase-I (topo-I) inhibitor Irinotecan (CPT-11), able to inhibit DNA topoisomerase I.
CAS Number:
86639-52-3
Purity:
≥98%
Molecular Weight:
392.41
Molecular Formula:
C22H20N2O5
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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SDS & Certificate of Analysis

SN 38 inhibits DNA and RNA synthesis (IC50 values are 0.077 and 1.3 µM respectively) but does not affect protein synthesis. SN 38 displays potent antitumor activity against a range of human tumor cell lines (IC50 values are 3.3, 13, 19 and 22 nM for HCT-116, BEL-7402, HL60 and HELA cells respectively). SN 38 is anctive metabolite of CPT-11 that inhibits DNA topoisomerase I (IC50 values are 0.74 and 1.9 μM in P388 and Ehrlich cells respectively). During hydrolysis, SN 38 is formed when the carboxylesterases metabolize irinotecan through glucuronidation by UDP glucuronosyl transferase 1A1. Compared to irinotecan, SN 38 is a more potent topoisomerase I inhibitor, and more cytotoxic to HT-29 colon cancer cells.


SN 38 (CAS 86639-52-3) References

  1. Inhibition of SN-38 glucuronidation by gefitinib and its metabolite.  |  Li, W., et al. 2015. Cancer Chemother Pharmacol. 75: 1253-60. PMID: 25917289
  2. Preparation and Characterization of SN-38-Encapsulated Phytantriol Cubosomes Containing α-Monoglyceride Additives.  |  Ali, MA., et al. 2016. Chem Pharm Bull (Tokyo). 64: 577-84. PMID: 27250792
  3. Gene-by-Environment Interaction of Bcrp-/- and Methionine- and Choline-Deficient Diet-Induced Nonalcoholic Steatohepatitis Alters SN-38 Disposition.  |  Toth, EL., et al. 2018. Drug Metab Dispos. 46: 1478-1486. PMID: 30166404
  4. SN-38, the active metabolite of irinotecan, inhibits the acute inflammatory response by targeting toll-like receptor 4.  |  Wong, DVT., et al. 2019. Cancer Chemother Pharmacol. 84: 287-298. PMID: 31011814
  5. Antibody-drug conjugates targeting TROP-2 and incorporating SN-38: A case study of anti-TROP-2 sacituzumab govitecan.  |  Goldenberg, DM. and Sharkey, RM. 2019. MAbs. 11: 987-995. PMID: 31208270
  6. Uremic serum residue decreases SN-38 sensitivity through suppression of organic anion transporter polypeptide 2B1 in LS-180 colon cancer cells.  |  Ozawa, S., et al. 2019. Sci Rep. 9: 15464. PMID: 31664047
  7. PLX038: a PEGylated prodrug of SN-38 independent of UGT1A1 activity.  |  Fontaine, SD., et al. 2020. Cancer Chemother Pharmacol. 85: 225-229. PMID: 31707444
  8. In vitro metabolic biomodulation of irinotecan to increase potency and reduce dose-limiting toxicity by inhibition of SN-38 glucuronide formation.  |  Crane, RA., et al. 2022. Drug Metab Pers Ther. 37: 295-303. PMID: 35257538
  9. The semi-synthetic flavonoid 2',3',4'-trihydroxyflavone (2-D08) inhibits both SN-38- and cytokine-evoked increases in epithelial barrier permeability in an in vitro intestinal mucositis model.  |  Marsh, DT. and Smid, SD. 2022. Food Funct. 13: 11142-11152. PMID: 36205567
  10. SN-38 Sensitizes BRCA-Proficient Ovarian Cancers to PARP Inhibitors through Inhibiting Homologous Recombination Repair.  |  Lin, S., et al. 2022. Dis Markers. 2022: 7243146. PMID: 36267463
  11. SN-38, an active metabolite of irinotecan, enhances anti-PD-1 treatment efficacy in head and neck squamous cell carcinoma.  |  Lee, YM., et al. 2023. J Pathol. 259: 428-440. PMID: 36641765
  12. Preclinical evaluation of CPT-11 and its active metabolite SN-38.  |  Lavelle, F., et al. 1996. Semin Oncol. 23: 11-20. PMID: 8633248
  13. SN-38, a metabolite of the camptothecin derivative CPT-11, potentiates the cytotoxic effect of radiation in human colon adenocarcinoma cells grown as spheroids.  |  Omura, M., et al. 1997. Radiother Oncol. 43: 197-201. PMID: 9192967

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

SN 38, 10 mg

sc-203697
10 mg
$119.00

SN 38, 50 mg

sc-203697A
50 mg
$342.00

SN 38, 500 mg

sc-203697B
500 mg
$883.00

Hi, do you have any UV data available for SN-38? Also any solubility information in THF?

Asked by: sgcarmst
Thank you for your question. SN 38 (CAS 86639-52-3) sc-203697 is soluble in DMSO at a concentration of 100 mM. You can download lot-specific certificates of analysis by providing the lot number of the product on its product page. For further information, or if you have no lot number available, please contact our technical service.
Answered by: SCBT Heidelberg Support
Date published: 2018-12-21

Do you have information about the storage and stability for the SN38 in DMSO ?

Asked by: Jbio
Thank you for your question. We recommend that solutions be used the same day they are made. If you need to store the solution we recommend to aliquot into useable amounts and freeze for up to 1 month. Multiple freeze/thaw cycles should be avoided.
Answered by: Technical Support
Date published: 2017-10-26

Why it is named as SN-38

Asked by: Shilpi Prasad
Thank you for your your question. This chemical has been assigned CAS number 86639-52-3 and is known by many alternate names including SN 38, and 7-Ethyl-10-hydroxycamptothecin. We do not have any information about how it was named.
Answered by: Technical Support
Date published: 2017-08-21
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Rated 5 out of 5 by from Bon produit conforme aux attentesproduit acheté suite à une rupture de stock de notre fournisseur et très satisfait du résultat qui fut conforme aux attentes. les résultats obtenus étaient similaire à notre autre référence. de plus livraison extrêmement rapide!
Date published: 2017-10-23
Rated 5 out of 5 by from Routinely use this in our labRoutinely use this in our lab, always works well for us.
Date published: 2015-03-13
Rated 5 out of 5 by from An increase in p21 protein expression wasAn increase in p21 protein expression was observed by WB in HCT 116 cells after treatment with SN 38. -SCBT QC
Date published: 2015-02-11
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SN 38 is rated 5.0 out of 5 by 3.
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