MKS3 Activators
MKS3 activators encompass a variety of chemical compounds that indirectly stimulate MKS3's functional activity through several distinct signaling pathways. Forskolin, Cholera Toxin, Milrinone, IBMX, Zinc Pyrithione, and Dibutyryl cAMP all function to elevate intracellular cAMP levels, leading to the activation of PKA. This activation may result in the phosphorylation of various proteins that interact with the MKS3 protein, thereby enhancing its role in ciliary function and signaling. The PDE inhibitors, specifically, prevent the breakdown of cAMP, supporting a sustained PKA signal that may act on the MKS3 pathways. Additionally, GTPγS acts as a G-protein activator, and this persistent activation could modify G-protein coupled receptor signaling, potentially affecting MKS3-regulated pathways.
Furthermore, the use of L-Arginine and Nitric Oxide Donor - Sodium Nitroprusside leads to the production of nitric oxide, which can elevate cGMP levels, thereby enhancing signaling mechanisms that may indirectly activate MKS3 involved in ciliary motion or sensory functions. AICAR, mimicking adenosine monophosphate, activates AMPK, which might influence MKS3 activity via energy balance and metabolic signals. The action of the calcium ionophore A23187 raises intracellular calcium levels, potentially impacting CaMK and subsequently MKS3-related signaling within cilia. Lastly, the Epac activator, 8-pCPT-2'-O-Me-cAMP, specifically targets Epac, which can modulate distinct cAMP-dependent pathways, potentially impacting the functional activity of MKS3 in the context of ciliary maintenance and signaling processes. Collectively, these activators function through biochemical pathways that converge on or influence the activity of MKS3, thereby enhancing its role in ciliary biology without directly increasing its expression or through general activation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, leading to increased levels of cAMP. Elevated cAMP can enhance protein kinase A (PKA) activity, which may phosphorylate specific substrates and proteins, potentially influencing MKS3 activity in ciliary functions. | ||||||
Milrinone | 78415-72-2 | sc-201193 sc-201193A | 10 mg 50 mg | $162.00 $683.00 | 7 | |
Milrinone, a phosphodiesterase inhibitor, prevents cAMP breakdown, thereby maintaining PKA activity. Through PKA, Milrinone could indirectly enhance MKS3 activity by affecting ciliary transport mechanisms or other related processes. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a nonspecific inhibitor of phosphodiesterases, leading to increased cAMP and cGMP levels in cells, which may bolster PKA activity. This enhancement could, in turn, influence the cellular processes that regulate MKS3 function in ciliogenesis. | ||||||
L-Arginine | 74-79-3 | sc-391657B sc-391657 sc-391657A sc-391657C sc-391657D | 5 g 25 g 100 g 500 g 1 kg | $20.00 $30.00 $60.00 $215.00 $345.00 | 2 | |
L-Arginine is a substrate for nitric oxide synthase, which generates nitric oxide, a signaling molecule that can activate guanylyl cyclase to increase cGMP levels. Elevated cGMP could modulate pathways influencing MKS3 activity in ciliary signaling. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc Pyrithione is known to increase intracellular cAMP by inhibiting phosphodiesterases. The resultant rise in cAMP may enhance PKA signaling, which could indirectly boost MKS3 activity by modulating proteins and pathways related to ciliogenesis. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl cAMP is a cell-permeable cAMP analog that directly elevates intracellular cAMP levels, stimulating PKA. PKA activation could then potentially enhance MKS3 function by modifying key proteins involved in ciliary structure and function. | ||||||
Guanosine 5′-O-(3-thiotriphosphate) tetralithium salt | 94825-44-2 | sc-202639 | 10 mg | $456.00 | ||
GTPγS is a non-hydrolyzable GTP analog which can irreversibly activate G-proteins, leading to downstream signaling effects that may impact pathways involving MKS3, particularly in the regulation of ciliary development and function. | ||||||
Sodium nitroprusside dihydrate | 13755-38-9 | sc-203395 sc-203395A sc-203395B | 1 g 5 g 100 g | $42.00 $83.00 $155.00 | 7 | |
Sodium Nitroprusside releases nitric oxide which can activate guanylyl cyclase, increasing cGMP levels. This increase in cGMP may have downstream effects on signaling pathways that enhance MKS3 activity in ciliary maintenance and signaling. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
AICAR mimics adenosine monophosphate (AMP) and can activate AMP-activated protein kinase (AMPK). Activation of AMPK may impact cellular energy balance, which could play a role in modulating MKS3 activity within ciliary function and homeostasis. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 increases intracellular calcium levels, which could activate calcium/calmodulin-dependent protein kinases (CaMK). These kinases may influence signaling cascades that modulate MKS3 activity, particularly in ciliary structure and signaling. | ||||||