MIZIP Inhibitors
MIZIP Inhibitors primarily target the RhoA/ROCK/SRF signaling cascade, given MIZIP's function in repressing myocardin, a key coactivator of SRF. By targeting this pathway, the inhibitors can modulate the influence of MIZIP on SRF-responsive genes. Compounds like CCG-1423 and CCG-203971 directly inhibit RhoA-induced SRF-mediated transcription, which makes them particularly pertinent to MIZIP's indirect regulatory effects via myocardin. Additionally, ROCK inhibitors such as Y-27632 and H-1152 further demonstrate the interconnectedness of the Rho/ROCK/SRF pathway.
The significance of actin dynamics and myosin interaction becomes apparent with the inclusion of actin modulators like Cytochalasin D, Jasplakinolide, and Latrunculin A. These compounds influence actin polymerization and depolymerization, with direct ramifications for SRF-responsive genes, which are closely associated with actin dynamics. This intricately woven system showcases the necessity of actin-myosin modulators, including Blebbistatin and ML-7. Rho-specific regulators like NSC 23766 further bolster the potential list of MIZIP modulators. While the Wnt pathway inhibitors, Wnt-C59 and FH535, were incorporated due to the known crosstalk with Rho/ROCK signaling, they signify the intricacy and interconnectedness of cellular pathways.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
CCG-1423 | 285986-88-1 | sc-205241 sc-205241A | 1 mg 5 mg | $30.00 $90.00 | 8 | |
Inhibitor of RhoA-induced SRF-mediated transcription. As MIZIP affects SRF via myocardin, CCG-1423 can indirectly influence MIZIP. | ||||||
CCG 203971 | 1443437-74-8 | sc-507360 | 10 mg | $89.00 | ||
Rho/MKL/SRF signaling pathway inhibitor, which may alter MIZIP's ability to repress myocardin-mediated transcription. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Rho-associated protein kinase (ROCK) inhibitor which can modulate SRF activity, thereby indirectly affecting MIZIP's function. | ||||||
H-1152 dihydrochloride | 451462-58-1 | sc-203592 sc-203592A | 1 mg 5 mg | $102.00 $357.00 | 7 | |
Another ROCK inhibitor, modulating SRF-mediated transcription, which MIZIP influences through myocardin. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $145.00 $442.00 | 64 | |
Actin polymerization inhibitor. As SRF-responsive genes are actin-associated, this can influence MIZIP's indirect targets. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $180.00 $299.00 | 59 | |
Actin polymerization stimulant. It can modulate actin dynamics and potentially influence SRF-responsive genes and MIZIP's activity. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $260.00 $799.00 | 36 | |
Binds to actin monomers, preventing polymerization. It can modulate SRF-responsive genes and MIZIP's indirect function. | ||||||
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $179.00 $307.00 $455.00 $924.00 $1689.00 | 7 | |
Myosin II inhibitor. By altering actin-myosin dynamics, it can influence SRF-responsive genes which are linked to MIZIP's activity. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $89.00 $262.00 | 13 | |
Inhibits myosin light chain kinase. Affects actin-myosin interaction and may influence SRF-responsive genes and MIZIP's role. | ||||||
Wnt-C59 | 1243243-89-1 | sc-475634 sc-475634A sc-475634B | 5 mg 10 mg 50 mg | $210.00 $320.00 $1250.00 | 1 | |
Wnt pathway inhibitor. While Wnt is mentioned, it is included due to crosstalk with Rho/ROCK signaling which MIZIP might be involved. | ||||||