CCG 203971 (CAS 1443437-74-8)
Alternate Names:
CCG-203971 CCG203971 N-(4-Chlorophenyl)-1-[3-(2-furanyl)benzoyl]-3-piperidinecarboxamide N-(4-chlorophenyl)-1-(3-(furan-2-yl)benzoyl)piperidine-3-carboxamide
CAS Number:
1443437-74-8
Molecular Weight:
408.90
Molecular Formula:
C23H21ClN2O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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CCG 203971 (CAS 1443437-74-8) References
- Inhibition of myocardin-related transcription factor/serum response factor signaling decreases lung fibrosis and promotes mesenchymal cell apoptosis. | Sisson, TH., et al. 2015. Am J Pathol. 185: 969-86. PMID: 25681733
- Stereospecific Inhibitory Effects of CCG-1423 on the Cellular Events Mediated by Myocardin-Related Transcription Factor A. | Watanabe, B., et al. 2015. PLoS One. 10: e0136242. PMID: 26295164
- Pharmacological Inhibition of Myocardin-related Transcription Factor Pathway Blocks Lung Metastases of RhoC-Overexpressing Melanoma. | Haak, AJ., et al. 2017. Mol Cancer Ther. 16: 193-204. PMID: 27837031
- Pharmacokinetic optimitzation of CCG-203971: Novel inhibitors of the Rho/MRTF/SRF transcriptional pathway as potential antifibrotic therapeutics for systemic scleroderma. | Hutchings, KM., et al. 2017. Bioorg Med Chem Lett. 27: 1744-1749. PMID: 28285914
- Local delivery of novel MRTF/SRF inhibitors prevents scar tissue formation in a preclinical model of fibrosis. | Yu-Wai-Man, C., et al. 2017. Sci Rep. 7: 518. PMID: 28364121
- A conditionally immortalized Gli1-positive kidney mesenchymal cell line models myofibroblast transition. | Ó hAinmhire, E., et al. 2019. Am J Physiol Renal Physiol. 316: F63-F75. PMID: 30303712
- Myocardin and myocardin-related transcription factor-A synergistically mediate actin cytoskeletal-dependent inhibition of liver fibrogenesis. | Shi, Z., et al. 2020. Am J Physiol Gastrointest Liver Physiol. 318: G504-G517. PMID: 31928221
- Identification of Pirin as a Molecular Target of the CCG-1423/CCG-203971 Series of Antifibrotic and Antimetastatic Compounds. | Lisabeth, EM., et al. 2019. ACS Pharmacol Transl Sci. 2: 92-100. PMID: 32039344
- Interplay of the transcription factor MRTF-A and matrix stiffness controls mammary acinar structure and protrusion formation. | Melcher, ML., et al. 2022. Cell Commun Signal. 20: 158. PMID: 36229824
- Inhibitors of Rho/MRTF/SRF Transcription Pathway Regulate Mitochondrial Function. | Patyal, P., et al. 2024. Cells. 13: PMID: 38474356
Inhibitor of:
BACE2, BBS9, DDX12, DDX25, Fc ε RIγ, FHOD1, Filamin 2, Gα 12, Gα 13, Gα i-3, HERPUD2, IKKα, MIZIP, MRTF-A, MRTF-B, MYH9, PITHD1, PRPK, PSTPIP2, Rad21, RGS6, Rho G, Rho GDI, RPGRIP1L, and SRF.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CCG 203971, 10 mg | sc-507360 | 10 mg | $89.00 |