MIPOL1 Activators
MIPOL1 Activators encompass a variety of chemical compounds that enhance the functional activity of MIPOL1 through distinct yet interconnected signaling pathways. Forskolin and Isoproterenol, by raising intracellular cAMP levels, indirectly augment MIPOL1 activity via PKA activation, which is known to phosphorylate targets that could be involved with MIPOL1-related cellular processes. Similarly, 8-Bromo-cAMP serves as a cAMP analog, promoting PKA-mediated signaling that potentially facilitates MIPOL1's role in the cell. PMA and 1,2-Dioctanoyl-sn-glycerol, both PKC activators, and Bisindolylmaleimide I, a PKC inhibitor, modulate this kinase's activity, leading to altered protein phosphorylation landscapes that can indirectly affect MIPOL1 activity. The compounds Ionomycin and A23187 enhance intracellular calcium signaling, a pathway that could intersect with MIPOL1's function, especially in cellular dynamics and transport mechanisms.
In addition, LY294002's inhibition of PI3K alters AKT signaling, which can intersect with MIPOL1's role in cellular growth and survival, potentially enhancing its activity. Okadaic Acid prevents dephosphorylation of proteins that may regulate MIPOL1, indirectly leading to an increase in MIPOL1's functional activity. U73122, by inhibiting PLC, affects downstream signaling events that can indirectly enhance MIPOL1's activity by altering the cytoskeletal organization and cell signaling. Epigallocatechin Gallate (EGCG), with its inhibitory effects on multiple kinases, could also create a biochemical environment conducive to MIPOL1 activation, particularly in pathways related to the cellular stress response and metabolism. Collectively, these MIPOL1 Activators operate through a network of signaling pathways to enhance the protein's functional activity without increasing its expression levels or direct activation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is a diterpenoid that activates adenylyl cyclase, leading to an increase in cyclic AMP (cAMP) levels. Elevated cAMP activates PKA (protein kinase A), which can phosphorylate various targets, including factors that may interact with MIPOL1, thereby enhancing its functional activity related to cellular processes such as division and migration. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a diester of phorbol and functions as a potent activator of protein kinase C (PKC). PKC modulates the activity of several proteins through phosphorylation. Activation of PKC can lead to phosphorylation events that may indirectly enhance the activity of MIPOL1 through altered cytoskeletal dynamics and cellular signaling pathways. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium concentrations. The rise in calcium can activate calcium-dependent signaling pathways, which could indirectly enhance the functional activity of MIPOL1, particularly in pathways related to cellular morphology and motility. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a synthetic catecholamine and beta-adrenergic agonist that increases intracellular levels of cAMP. This elevation in cAMP can lead to activation of PKA, which in turn can phosphorylate proteins that interact with or regulate MIPOL1 function, leading to its enhanced activity in cellular signaling. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
8-Bromo-cAMP is a cell-permeable cAMP analog that activates cAMP-dependent pathways. By mimicking cAMP, it activates PKA, which can then phosphorylate substrates that may regulate MIPOL1's activity, thus indirectly enhancing MIPOL1's functional role. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases PP1 and PP2A. Inhibition of these phosphatases leads to increased phosphorylation levels of proteins, which could result in the enhancement of MIPOL1 activity by preventing the dephosphorylation of proteins that interact with or regulate MIPOL1. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is a calcium ionophore that facilitates the influx of calcium ions into cells, enhancing intracellular calcium signaling. Elevated calcium signaling can affect various proteins and pathways that may indirectly increase the activity of MIPOL1, particularly in processes like vesicle transport or cytoskeletal organization. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a specific inhibitor of PI3K (phosphoinositide 3-kinases). By inhibiting PI3K, LY294002 can modulate AKT signaling pathways, potentially resulting in the enhancement of MIPOL1 activity by altering cellular survival and growth pathways that intersect with MIPOL1 functions. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $105.00 $242.00 | 36 | |
Bisindolylmaleimide I is a specific inhibitor of PKC. Its inhibition of PKC can lead to changes in phosphorylation patterns of proteins that interact with MIPOL1, potentially enhancing MIPOL1's role in cellular pathways by affecting cytoskeletal dynamics and cell adhesion processes. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is a polyphenol found in green tea with various biological activities, including inhibition of several kinases. This broad kinase inhibition may lead to the enhancement of MIPOL1 activity by impacting signaling pathways that are involved in cellular stress responses and metabolism that MIPOL1 may modulate. | ||||||