MIP-1β Activators
MIP-1β activators embrace a range of chemicals that, directly or indirectly, modulate the expression or activity of MIP-1β, a key player in immune responses and inflammation. By considering the broader context of immune regulation and activation, it becomes apparent that several pathways converge to influence the production of this chemokine. For instance, Lipopolysaccharide (LPS) is a classic stimulant of macrophages, inducing the production of numerous cytokines, including MIP-1β. Phorbol 12-myristate 13-acetate (PMA) serves as another potent stimulant, acting through protein kinase C activation and thereby inciting a cascade of cellular responses.
A deep dive into the pattern of activators reveals an over-representation of toll-like receptor (TLR) agonists like R848 and Imiquimod. These agonists simulate the presence of pathogens, subsequently triggering the innate immune response, which includes the secretion of cytokines like MIP-1β. Beyond TLRs, other stimuli such as the calcium ionophore A23187 showcases the depth of cellular mechanics at play, highlighting how alterations in intracellular calcium can stir the production of MIP-1β.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lipopolysaccharide, E. coli O55:B5 | 93572-42-0 | sc-221855 sc-221855A sc-221855B sc-221855C | 10 mg 25 mg 100 mg 500 mg | $98.00 $171.00 $425.00 $1560.00 | 12 | |
Known to activate macrophages and induce the production of MIP-1β among other cytokines. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Activates protein kinase C, leading to cellular responses including MIP-1β secretion. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
Increases intracellular calcium, which can stimulate the production of MIP-1β. | ||||||
Polyinosinic acid - polycytidylic acid sodium salt, double-stranded | 42424-50-0 | sc-204854 sc-204854A | 10 mg 100 mg | $139.00 $663.00 | 2 | |
Mimics viral double-stranded RNA, leading to activation of immune cells and cytokine production. | ||||||
R-848 | 144875-48-9 | sc-203231 sc-203231A sc-203231B sc-203231C | 5 mg 25 mg 100 mg 500 mg | $102.00 $306.00 $510.00 $1559.00 | 12 | |
TLR7/8 agonist, induces production of cytokines including MIP-1β. | ||||||
Imiquimod | 99011-02-6 | sc-200385 sc-200385A | 100 mg 500 mg | $67.00 $284.00 | 6 | |
TLR7 agonist known to stimulate cytokine production. | ||||||
Pam3Cys-Ser-(Lys)4, Hydrochloride | 112208-00-1 | sc-507471 | 2 mg | $550.00 | ||
TLR1/2 agonist that induces immune activation and cytokine release. | ||||||
Zymosan A from Saccharomyces cerevisiae | 58856-93-2 | sc-258367 sc-258367A | 250 mg 1 g | $90.00 $222.00 | 2 | |
Can stimulate macrophages and lead to production of various cytokines, including MIP-1β. | ||||||
Gardiquimod | 1020412-43-4 | sc-221663 sc-221663A sc-221663B sc-221663C sc-221663D sc-221663E sc-221663F | 25 mg 50 mg 100 mg 250 mg 5 g 10 g 25 g | $157.00 $282.00 $516.00 $1177.00 $20138.00 $32779.00 $70753.00 | 1 | |
A TLR7 agonist that induces the secretion of cytokines including MIP-1β. | ||||||
L-Arginine | 74-79-3 | sc-391657B sc-391657 sc-391657A sc-391657C sc-391657D | 5 g 25 g 100 g 500 g 1 kg | $20.00 $31.00 $61.00 $219.00 $352.00 | 2 | |
Can induce the secretion of MIP-1β from certain immune cells. | ||||||