Mina53 Inhibitors
Mina53 inhibitors modulate specific cellular processes. Mina53, also known as MTF1-interacting nuclear protein, is a multifunctional protein that is primarily localized in the nucleus of cells. It plays a versatile role in various cellular processes, including gene expression regulation, chromatin remodeling, and mRNA splicing. Mina53 is known to interact with transcription factors, co-regulators, and chromatin modifiers, influencing the transcriptional activity of specific genes and impacting various aspects of cellular physiology. Mina53 inhibitors interact with the active site or binding domain of the Mina53 protein, effectively inhibiting its function and potentially influencing cellular processes dependent on Mina53-mediated gene regulation and protein-protein interactions.
Structurally, Mina53 inhibitors target the active site or binding domains of Mina53. By inhibiting Mina53, these compounds may disrupt its role in regulating gene expression, chromatin dynamics, and mRNA processing, potentially leading to alterations in cellular responses and gene expression patterns. The study of Mina53 inhibitors is of significant interest to researchers as it provides insights into the regulatory mechanisms governing essential cellular functions, particularly in the context of transcriptional regulation and chromatin remodeling. This knowledge contributes to our understanding of basic cell biology and may have implications in various research areas, including cancer biology, cellular differentiation, and the molecular basis of diseases associated with aberrant gene expression and protein-protein interactions involving Mina53.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D intercalates into DNA, inhibiting RNA polymerase and thus blocking transcription initiation, which could lead to decreased expression of genes such as MINA. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $88.00 $200.00 | 13 | |
Triptolide has been shown to inhibit RNA polymerase I, II, and III activities, likely reducing the transcription of a variety of genes, including MINA. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $260.00 $1029.00 | 26 | |
α-Amanitin specifically inhibits RNA polymerase II, decreasing mRNA synthesis for genes transcribed by this enzyme, likely reducing Mina53 expression. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor that changes chromatin structure, potentially downregulating genes involved in cell cycle progression, including possibly MINA. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine raises endosomal pH, which can affect cell signaling and transcription factor activities, potentially reducing the expression of certain genes, including MINA. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate inhibits histone deacetylases, leading to hyperacetylated chromatin and affecting gene expression, potentially including MINA gene expression. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a nucleoside analog that can incorporate into RNA and DNA, inhibiting methyltransferase, which might result in the reactivation of genes or suppression of others, including MINA. | ||||||
Rocaglamide | 84573-16-0 | sc-203241 sc-203241A sc-203241B sc-203241C sc-203241D | 100 µg 1 mg 5 mg 10 mg 25 mg | $270.00 $465.00 $1607.00 $2448.00 $5239.00 | 4 | |
Rocaglamide has been shown to inhibit translation initiation, potentially leading to reduced protein synthesis broadly, including the reduction of Mina53 levels. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $226.00 $846.00 | 1 | |
JQ1 is a BET bromodomain inhibitor that impacts transcription regulation and could potentially downregulate a range of genes, possibly including those coding for proteins like Mina53. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
Decitabine is a DNA methyltransferase inhibitor leading to hypomethylation of DNA and alterations in gene expression, which may affect the expression of MINA. | ||||||