Mina53 Antibody (H-4): sc-398521
- Mina53 Antibody (H-4) is a mouse monoclonal IgG1 κ Mina53 antibody, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 110-165 mapping within an internal region of Mina53 of human origin
- Mina53 Antibody (H-4) is recommended for detection of Mina53 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-Mina53 Antibody (H-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Mina53 Antibody (H-4) for WB applications. These reagents are now offered in bundles with Mina53 Antibody (H-4) (see ordering information below).
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Mina53 Antibody (H-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects Mina53 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-Mina53 antibody (H-4) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Mina53 protein, also known as MINA (MYC induced nuclear antigen), MDIG, or NO52, is a 465 amino acid protein characterized by the presence of a JmjC domain and is primarily localized in the nucleus. This localization positions Mina53 at the center of ribosome biogenesis, where Mina53 plays a significant role in the assembly of pre-ribosomal particles. By facilitating ribosome assembly, Mina53 is essential for cell growth, survival, and overall cellular proliferation, making Mina53 a key player in maintaining normal cellular functions. Notably, Mina53 expression is upregulated in various cancers, including esophageal squamous cell carcinoma, colon cancer, and lung cancer, indicating Mina53′s potential involvement in tumorigenesis. Additionally, multiple isoforms of Mina53 exist due to alternative splicing events, adding complexity to Mina53′s functional roles in cellular processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Mina53 Antibody (H-4) References:
- A novel myc target gene, mina53, that is involved in cell proliferation. | Tsuneoka, M., et al. 2002. J Biol Chem. 277: 35450-9. PMID: 12091391
- Increased expression of a Myc target gene Mina53 in human colon cancer. | Teye, K., et al. 2004. Am J Pathol. 164: 205-16. PMID: 14695334
- Mina53 as a potential prognostic factor for esophageal squamous cell carcinoma. | Tsuneoka, M., et al. 2004. Clin Cancer Res. 10: 7347-56. PMID: 15534111
- Protein NO52--a constitutive nucleolar component sharing high sequence homologies to protein NO66. | Eilbracht, J., et al. 2005. Eur J Cell Biol. 84: 279-94. PMID: 15819408
- The Human mineral dust-induced gene, mdig, is a cell growth regulating gene associated with lung cancer. | Zhang, Y., et al. 2005. Oncogene. 24: 4873-82. PMID: 15897898
- Expression of Myc target gene mina53 in subtypes of human lymphoma. | Teye, K., et al. 2007. Oncol Rep. 18: 841-8. PMID: 17786344
- Overexpression of the myc target gene Mina53 in advanced renal cell carcinoma. | Ishizaki, H., et al. 2007. Pathol Int. 57: 672-80. PMID: 17803656
- Expression of Mina53 and its significance in gastric carcinoma. | Zhang, Q., et al. 2008. Int J Biol Markers. 23: 83-8. PMID: 18629780
- Potential effects of Mina53 on tumor growth in human pancreatic cancer. | Tan, XP., et al. 2014. Cell Biochem Biophys. 69: 619-25. PMID: 24522517
- Molecular Signatures of JMJD10/MINA53 in Gastric Cancer. | Aziz, N., et al. 2020. Cancers (Basel). 12: PMID: 32370161
- First-in-Class Inhibitors of the Ribosomal Oxygenase MINA53. | Nowak, RP., et al. 2021. J Med Chem. 64: 17031-17050. PMID: 34843649
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Mina53 Antibody (H-4) | sc-398521 | 200 µg/ml | $322.00 | |||
Mina53 Antibody (H-4): m-IgG Fc BP-HRP Bundle | sc-530831 | 200 µg Ab; 10 µg BP | $361.00 | |||
Mina53 Antibody (H-4): m-IgGκ BP-HRP Bundle | sc-524377 | 200 µg Ab, 40 µg BP | $361.00 | |||
Mina53 Antibody (H-4): m-IgG1 BP-HRP Bundle | sc-544270 | 200 µg Ab; 20 µg BP | $361.00 | |||
Mina53 Antibody (H-4) AC | sc-398521 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Mina53 Antibody (H-4) HRP | sc-398521 HRP | 200 µg/ml | $322.00 | |||
Mina53 Antibody (H-4) FITC | sc-398521 FITC | 200 µg/ml | $336.00 | |||
Mina53 Antibody (H-4) PE | sc-398521 PE | 200 µg/ml | $349.00 | |||
Mina53 Antibody (H-4) Alexa Fluor® 488 | sc-398521 AF488 | 200 µg/ml | $364.00 | |||
Mina53 Antibody (H-4) Alexa Fluor® 546 | sc-398521 AF546 | 200 µg/ml | $364.00 | |||
Mina53 Antibody (H-4) Alexa Fluor® 594 | sc-398521 AF594 | 200 µg/ml | $364.00 | |||
Mina53 Antibody (H-4) Alexa Fluor® 647 | sc-398521 AF647 | 200 µg/ml | $364.00 | |||
Mina53 Antibody (H-4) Alexa Fluor® 680 | sc-398521 AF680 | 200 µg/ml | $364.00 | |||
Mina53 Antibody (H-4) Alexa Fluor® 790 | sc-398521 AF790 | 200 µg/ml | $364.00 |