MIF4GD Inhibitors
MIF4GD inhibitors are chemical compounds that decrease the functional activity of MIF4GD. Resveratrol and Quercetin are compounds that inhibit the transcription and translation of MIF4GD, respectively. Resveratrol activates SIRT1, which leads to a tighter chromatin structure that restricts the access of the transcription machinery to the MIF4GD gene. On the other hand, Quercetin inhibits the PI3K/AKT pathway, which is known to positively regulate the translation of MIF4GD. The inhibition of this pathway can lead to a decrease in MIF4GD protein levels.
LY294002, Curcumin, PD98059, SP600125, SB203580, Rapamycin, Staurosporine, Cycloheximide, 5-Fluorouracil, and Azathioprine are compounds that inhibit the functional activity of MIF4GD through various mechanisms. LY294002, an inhibitor of PI3K, and Rapamycin, an inhibitor of mTOR, decrease the translation of MIF4GD by inhibiting their respective pathways. PD98059, SP600125, and SB203580 inhibit the ERK, JNK, and p38 MAPK pathways respectively, leading to a decrease in the stability of MIF4GD. Curcumin inhibits NF-κB, reducing the transcription of MIF4GD. Staurosporine, a broad-spectrum kinase inhibitor, can inhibit various pathways that positively regulate the translation and stability of MIF4GD. Cycloheximide, by inhibiting protein synthesis, can lead to a decrease in MIF4GD protein levels. 5-Fluorouracil and Azathioprine inhibit DNA synthesis and purine synthesis respectively, leading to decreased transcription and translation of MIF4GD.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin can inhibit PI3K/AKT pathway by reducing the phosphorylation of AKT. Since this pathway is known to positively regulate the translation of MIF4GD, its inhibition can lead to decreased MIF4GD protein levels. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a specific inhibitor of PI3K, an upstream regulator of AKT. Inhibition of PI3K by LY294002 can lead to decreased AKT activity, which can reduce the translation of MIF4GD, leading to decreased MIF4GD protein levels. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin can inhibit NF-κB, a transcription factor that influences the transcription of MIF4GD. Inhibition of NF-κB can lead to reduced MIF4GD transcription and hence decreased MIF4GD protein levels. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is an inhibitor of MEK, a part of the ERK pathway that is known to positively regulate the stability of MIF4GD. Inhibition of MEK can decrease MIF4GD stability, leading to its rapid degradation and decreased protein levels. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a JNK inhibitor. The JNK pathway upregulates the translation of MIF4GD. Inhibition of JNK can lead to decreased MIF4GD protein levels. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is an inhibitor of p38 MAPK, a pathway that positively regulates the stability of MIF4GD. Inhibition of p38 MAPK can decrease MIF4GD stability, leading to its rapid degradation and decreased protein levels. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is an inhibitor of mTOR, a pathway that positively regulates the translation of MIF4GD. Inhibition of mTOR by Rapamycin can lead to decreased MIF4GD protein levels. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a broad-spectrum kinase inhibitor that can inhibit various pathways that positively regulate the translation and stability of MIF4GD, leading to decreased MIF4GD protein levels. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
Cycloheximide is an inhibitor of protein synthesis. While it does not specifically target MIF4GD, its broad-spectrum inhibition of protein synthesis can lead to decreased MIF4GD protein levels. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
5-Fluorouracil is a pyrimidine analog that inhibits DNA synthesis. This can lead to decreased transcription of MIF4GD, resulting in decreased MIF4GD protein levels. | ||||||