MIF4GD Activators
MIF4GD Activators primarily consist of chemical compounds that have a direct or indirect impact on the specific pathways in which MIF4GD is involved. These activators, including Dexamethasone, RU486, Forskolin, Epinephrine, IBMX, Rapamycin, Resveratrol, Metformin, AICAR, 2-Deoxy-D-glucose, Retinoic acid, and Rosiglitazone, can enhance the functional activity of MIF4GD through specific signaling pathways. For instance, Dexamethasone and RU486 operate through the glucocorticoid receptor pathway, with Dexamethasone being a glucocorticoid that activates the GR pathway and RU486 acting as a glucocorticoid receptor antagonist that can indirectly enhance the activity of MIF4GD.
Furthermore, Forskolin and Epinephrine influence MIF4GD activity through the adenylate cyclase and adrenergic receptor pathways, respectively, leading to increased cAMP levels, which in turn can enhance MIF4GD activity. IBMXalso works through the cAMP pathway by decreasing cAMP degradation. Other compounds like Rapamycin, Resveratrol, Metformin, AICAR operate through the mTOR, SIRT1, and AMPK pathways, respectively, while 2-Deoxy-D-glucose influences the glycolytic pathway, thus leading to the enhanced activity of MIF4GD. Lastly, Retinoic acid and Rosiglitazone enhance MIF4GD activity via the Retinoic Acid Receptor and PPARγ-regulated pathways, respectively.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone is a glucocorticoid that can enhance MIF4GD’s functional activity. It achieves this by activating the glucocorticoid receptor (GR) pathway. MIF4GD is a known GR-responsive gene, and activation of the GR pathway can increase MIF4GD activity. | ||||||
Mifepristone | 84371-65-3 | sc-203134 | 100 mg | $61.00 | 17 | |
RU486 or mifepristone is a glucocorticoid receptor antagonist. In the presence of glucocorticoids, RU486 can indirectly enhance the activity of MIF4GD by creating a state of relative glucocorticoid resistance, leading to compensatory upregulation of glucocorticoid-responsive genes including MIF4GD. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is an activator of adenylate cyclase that increases cyclic AMP (cAMP) levels. Increased cAMP can enhance the functional activity of MIF4GD as it is known to activate downstream pathways involving cAMP-responsive genes. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine activates adrenergic receptors leading to an increase in cAMP levels. The resultant cAMP upregulation can enhance MIF4GD activity, due to its role in cAMP-responsive pathways. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX or 3-Isobutyl-1-methylxanthine is a nonspecific inhibitor of phosphodiesterase, an enzyme that degrades cAMP. By preventing cAMP degradation, IBMX can enhance the functional activity of MIF4GD. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is a known activator of SIRT1, a NAD-dependent deacetylase. SIRT1 activation can lead to enhanced MIF4GD activity as MIF4GD is involved in pathways regulated by SIRT1. | ||||||
1,1-Dimethylbiguanide, Hydrochloride | 1115-70-4 | sc-202000F sc-202000A sc-202000B sc-202000C sc-202000D sc-202000E sc-202000 | 10 mg 5 g 10 g 50 g 100 g 250 g 1 g | $20.00 $43.00 $63.00 $156.00 $260.00 $510.00 $31.00 | 37 | |
Metformin activates AMP-activated protein kinase (AMPK), which regulates energy homeostasis. Activation of AMPK can enhance the functional activity of MIF4GD as it is involved in AMPK-regulated pathways. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AICAR or 5-aminoimidazole-4-carboxamide ribonucleotide is an activator of AMPK. By activating AMPK, AICAR can enhance the functional activity of MIF4GD. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $70.00 $215.00 | 26 | |
2-Deoxy-D-glucose inhibits glycolysis leading to cellular energy stress. This cellular condition can enhance MIF4GD activity as it is involved in pathways responding to energy stress. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid activates retinoic acid receptor (RAR), and MIF4GD activity can be enhanced in the presence of activated RAR, as it is involved in RAR-responsive pathways. | ||||||