Date published: 2025-10-19

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MIF Inhibitors

MIF inhibitors belong to a chemical class designed to modulate the activity of macrophage migration inhibitory factor (MIF), a pro-inflammatory cytokine that plays a role in various immune and inflammatory responses. MIF is involved in the regulation of immune cell function, inflammation, cell proliferation, and other processes. Inhibitors targeting MIF aim to interfere with its signaling pathways or interactions with other molecules, influencing the downstream cellular responses that MIF is involved in.The development of MIF inhibitors is driven by the desire to gain a deeper understanding of MIF's role in inflammatory and immune processes. These inhibitors are designed to interact with MIF or its associated molecules, which may alter the cytokine's functions and provide insights into its intricate role in various physiological and pathological conditions. By elucidating the mechanisms through which MIF operates, researchers can uncover novel targets for intervention in inflammation-related diseases. The study of MIF inhibitors contributes to advancing our understanding of immune regulation and inflammation, paving the way for applications in various scientific and biomedical contexts.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

MIF Antagonist, ISO-1

478336-92-4sc-204807D
sc-204807
sc-204807A
sc-204807B
sc-204807C
1 mg
5 mg
10 mg
25 mg
50 mg
$47.00
$93.00
$179.00
$389.00
$772.00
5
(1)

Binds to MIF's tautomerase active site, inhibiting its enzymatic activity and downstream signaling effects.

Chicago Sky Blue 6B

2610-05-1sc-361146
sc-361146A
sc-361146B
25 g
100 g
250 g
$115.00
$320.00
$615.00
(1)

Chicago Sky Blue 6B exhibits unique molecular interactions that enhance its role as a MIF. Its distinct chromophoric structure allows for strong π-π stacking and hydrogen bonding, influencing its reactivity in dyeing processes. The compound's stability under varying pH conditions and its ability to form complexes with metal ions contribute to its kinetic behavior, facilitating rapid diffusion and adsorption in various environments. This dynamic interaction profile enhances its performance in diverse applications.

N4-Benzoyl-3′,5′-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)cytidine

69304-43-4sc-485741
1 g
$240.00
(0)

A small molecule inhibitor that targets the tautomerase active site of MIF, potentially modulating its functions.

Exendin-3 (9-39)

133514-43-9sc-364387
500 µg
$428.00
6
(0)

An inhibitor that disrupts MIF's interaction with its receptor, CD74, impacting MIF-mediated cellular responses.

3′,4′,7-Trihydroxyisoflavone

485-63-2sc-206722
200 mg
$295.00
1
(1)

A ligand that binds to MIF and inhibits its interaction with CD74, potentially attenuating MIF-related effects.

Epalrestat

82159-09-9sc-218319
10 mg
$200.00
2
(1)

An aldose reductase inhibitor that indirectly reduces MIF production and expression in cells.

Sivelestat

127373-66-4sc-203938
1 mg
$105.00
2
(1)

A neutrophil elastase inhibitor that may modulate MIF's effects by reducing neutrophil activation and inflammation.

Kuromanin chloride

7084-24-4sc-235457
1 mg
$215.00
1
(1)

A natural compound that has been suggested to inhibit MIF's pro-inflammatory effects by reducing its expression.

4-IPP

41270-96-6sc-361082
sc-361082A
10 mg
50 mg
$210.00
$822.00
3
(0)

Inhibits MIF's tautomerase activity, potentially affecting MIF's pro-inflammatory and immune-regulatory roles.