Molecular structure of Chicago Sky Blue 6B, CAS Number: 2610-05-1
Chicago Sky Blue 6B (CAS 2610-05-1)
Alternate Names:
Direct Blue 1; Pontamine sky blue
Application:
Chicago Sky Blue 6B is a potent inhibitor of L-glutamate uptake via glutamate transporter (EAAT)
CAS Number:
2610-05-1
Molecular Weight:
992.80
Molecular Formula:
C34H24N6O16S4•4Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Chicago Sky Blue 6B (CSB6B) is a luminous dye that generates light upon exposure to a specific wavelength of light. The emitted light corresponds to the quantity of Chicago Sky Blue 6B present, facilitating the measurement of molecules. Additionally, Chicago Sky Blue 6B has the capability to permeate cell membranes, enabling the observation of internal cellular structures and activities. Chicago Sky Blue 6B has been extensively employed to visualize and quantify diverse biological processes including endocytosis, cell cycle advancement, and apoptosis.
Chicago Sky Blue 6B (CAS 2610-05-1) References
- Transformation and degradation of the disazo dye Chicago Sky Blue by a purified laccase from Pycnoporus cinnabarinus. | Schliephake, K., et al. 2000. Enzyme Microb Technol. 27: 100-107. PMID: 10862908
- Practical tip: Chicago Sky Blue (CSB) stain can be added to the routine potassium hydroxide (KOH) wet-mount to provide a color contrast and facilitate the diagnosis of dermatomycoses. | Lim, CS. and Lim, SL. 2011. Dermatol Online J. 17: 11. PMID: 21906491
- Chicago sky blue 6B, a vesicular glutamate transporters inhibitor, attenuates methamphetamine-induced hyperactivity and behavioral sensitization in mice. | He, Z., et al. 2013. Behav Brain Res. 239: 172-6. PMID: 23159705
- The antinociceptive effects of intracerebroventricular administration of Chicago sky blue 6B, a vesicular glutamate transporter inhibitor. | Yu, G., et al. 2013. Behav Pharmacol. 24: 653-8. PMID: 24128751
- Comparison of modified Chicago sky blue stain and potassium hydroxide mount for the diagnosis of dermatomycoses and onychomycoses. | Liu, Z., et al. 2015. J Microbiol Methods. 112: 21-3. PMID: 25765148
- A Novel Contrast Stain for the Rapid Diagnosis of Pityriasis Versicolor: A Comparison of Chicago Sky Blue 6B Stain, Potassium Hydroxide Mount and Culture. | Lodha, N. and Poojary, SA. 2015. Indian J Dermatol. 60: 340-4. PMID: 26288400
- Comparative study of efficacy, rapidity of detection, and cost-effectiveness of potassium hydroxide, calcofluor white, and Chicago sky blue stains in the diagnosis of dermatophytoses. | Prakash, R., et al. 2016. Int J Dermatol. 55: e172-5. PMID: 26861859
- A comparison of conventional rapid methods in diagnosis of superficial and cutaneous mycoses based on KOH, Chicago sky blue 6B and calcofluor white stains. | Afshar, P., et al. 2018. Iran J Microbiol. 10: 433-440. PMID: 30873272
- The small molecule Chicago Sky Blue promotes heart repair following myocardial infarction in mice. | Yifa, O., et al. 2019. JCI Insight. 4: PMID: 31723055
- Chicago sky blue 6B (CSB6B), an allosteric inhibitor of macrophage migration inhibitory factor (MIF), suppresses osteoclastogenesis and promotes osteogenesis through the inhibition of the NF-κB signaling pathway. | Jin, K., et al. 2021. Biochem Pharmacol. 192: 114734. PMID: 34411569
- Chicago sky blue 6B inhibits α-synuclein aggregation and propagation. | Min, JO., et al. 2022. Mol Brain. 15: 27. PMID: 35346306
- Inhibition of Vesicular Glutamate Transporters (VGLUTs) with Chicago Sky Blue 6B Before Focal Cerebral Ischemia Offers Neuroprotection. | Pomierny, B., et al. 2023. Mol Neurobiol.. PMID: 36802054
- Uptake of L-glutamate into rat brain synaptic vesicles: effect of inhibitors that bind specifically to the glutamate transporter. | Roseth, S., et al. 1995. J Neurochem. 65: 96-103. PMID: 7790899
Inhibitor of:
EAAT, and MIF.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Chicago Sky Blue 6B, 25 g | sc-361146 | 25 g | $115.00 | |||
Chicago Sky Blue 6B, 100 g | sc-361146A | 100 g | $320.00 | |||
Chicago Sky Blue 6B, 250 g | sc-361146B | 250 g | $615.00 |