Molecular structure of MIF Antagonist, ISO-1, CAS Number: 478336-92-4
MIF Antagonist, ISO-1 (CAS 478336-92-4)
See product citations (5)
Alternate Names:
Macrophage Migration Inhibitory Factor Antagonist; ISO-1; (S,R)-3-(4-Hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid
Application:
MIF Antagonist, ISO-1 is a cell-permeable isoxazoline compound that displays anti-inflammatory properties
CAS Number:
478336-92-4
Purity:
≥95%
Molecular Weight:
235.24
Molecular Formula:
C12H13NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
MIF Antagonist, ISO-1 is a cell-permeable isoxazoline compound that displays anti-inflammatory properties. MIF Antagonist, ISO-1 inhibits MIF dopachrome tautomerase activity by binding to its catalytic active site (IC50 = 7 µM for D-dopachrome tautomerase) and suppresses the production of TNFalpha, PGE2 and COX-2 in human monocytes and arachidonic acid in RAW 264.7 macrophages. MIF Antagonist, ISO-1 may act to exhibit antidiabetogenic properties in immunoinflammatory diabetic mouse model.
MIF Antagonist, ISO-1 (CAS 478336-92-4) References
- The tautomerase active site of macrophage migration inhibitory factor is a potential target for discovery of novel anti-inflammatory agents. | Lubetsky, JB., et al. 2002. J Biol Chem. 277: 24976-82. PMID: 11997397
- Critical role of macrophage migration inhibitory factor activity in experimental autoimmune diabetes. | Cvetkovic, I., et al. 2005. Endocrinology. 146: 2942-51. PMID: 15790730
- A fluorinated analog of ISO-1 blocks the recognition and biological function of MIF and is orally efficacious in a murine model of colitis. | Dagia, NM., et al. 2009. Eur J Pharmacol. 607: 201-12. PMID: 19239912
- ISO-1, a macrophage migration inhibitory factor antagonist, inhibits airway remodeling in a murine model of chronic asthma. | Chen, PF., et al. 2010. Mol Med. 16: 400-8. PMID: 20485865
- ISO-1, a macrophage migration inhibitory factor antagonist, prevents N-methyl-D-aspartate-induced retinal damage. | Naruoka, T., et al. 2013. Eur J Pharmacol. 718: 138-44. PMID: 24041932
- MIF Inhibitor ISO-1 Protects Photoreceptors and Reduces Gliosis in Experimental Retinal Detachment. | Kim, B., et al. 2017. Sci Rep. 7: 14336. PMID: 29084983
- Protective effect of ISO‑1 against advanced glycation end product aggravation of PC12 cell injury induced by Aβ1‑40. | Yu, M., et al. 2019. Mol Med Rep. 20: 2135-2142. PMID: 31322215
- MIF inhibitor, ISO-1, attenuates human pancreatic cancer cell proliferation, migration and invasion in vitro, and suppresses xenograft tumour growth in vivo. | Cheng, B., et al. 2020. Sci Rep. 10: 6741. PMID: 32317702
- Protective Mechanism of MIF Inhibitor ISO-1 on Intrahepatic Bile Duct Cells in Rats with Severe Acute Pancreatitis. | Wang, B., et al. 2021. Dig Dis Sci. 66: 3415-3426. PMID: 33123939
- Protective effect of ISO-1 with inhibition of RIPK3 up-regulation and neutrophilic accumulation on acetaminophen-induced liver injury in mice. | Ohkawara, T., et al. 2021. Toxicol Lett. 339: 51-59. PMID: 33370591
- MIF inhibitor ISO-1 alleviates severe acute pancreatitis-associated acute kidney injury by suppressing the NLRP3 inflammasome signaling pathway. | Liu, Y., et al. 2021. Int Immunopharmacol. 96: 107555. PMID: 33823428
- Macrophage migration inhibitory factor (MIF) inhibitor iSO-1 promotes staphylococcal protein A-induced osteogenic differentiation by inhibiting NF-κB signaling pathway. | Shi, X., et al. 2023. Int Immunopharmacol. 115: 109600. PMID: 36577150
- Ischemic stroke protected by ISO-1 inhibition of apoptosis via mitochondrial pathway. | Ji, W., et al. 2023. Sci Rep. 13: 2788. PMID: 36797398
Inhibitor of:
ChoK, MIF, and TNF alpha.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MIF Antagonist, ISO-1, 1 mg | sc-204807D | 1 mg | $47.00 | |||
MIF Antagonist, ISO-1, 5 mg | sc-204807 | 5 mg | $93.00 | |||
MIF Antagonist, ISO-1, 10 mg | sc-204807A | 10 mg | $179.00 | |||
MIF Antagonist, ISO-1, 25 mg | sc-204807B | 25 mg | $389.00 | |||
MIF Antagonist, ISO-1, 50 mg | sc-204807C | 50 mg | $772.00 |