Molecular structure of 3′,4′,7-Trihydroxyisoflavone, CAS Number: 485-63-2
3′,4′,7-Trihydroxyisoflavone (CAS 485-63-2)
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Alternate Names:
3-(3,4-dihydroxyphenyl)-7-hydroxychromen-4-one
Application:
3′,4′,7-Trihydroxyisoflavone is an inhibitor of β-galactosidase enzyme
CAS Number:
485-63-2
Molecular Weight:
270.25
Molecular Formula:
C15H10O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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3′,4′,7-Trihydroxyisoflavone (THIF) is a flavonoid molecule found in plant-based foods, including soy, legumes, and green tea. It inhibits beta-galactosidase enzyme, Cdk, Cot, MEK-4 and PI 3-kinase. It may act to possess anti-inflammatory, anti-cancer, anti-diabetic, cardioprotective, and anti-aging properties. In particular, 3′,4′,7-Trihydroxyisoflavone inhibits the production of pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and interleukin-1beta (IL-1β), as well as the proliferation of cancer cells.
3′,4′,7-Trihydroxyisoflavone (CAS 485-63-2) References
- ortho-dihydroxyisoflavone derivatives from aged Doenjang (Korean fermented soypaste) and its radical scavenging activity. | Park, JS., et al. 2008. Bioorg Med Chem Lett. 18: 5006-9. PMID: 18722771
- Regioselective hydroxylation of isoflavones by Streptomyces avermitilis MA-4680. | Roh, C., et al. 2009. J Biosci Bioeng. 108: 41-6. PMID: 19577190
- A-ring ortho-specific monohydroxylation of daidzein by cytochrome P450s of Nocardia farcinica IFM10152. | Choi, KY., et al. 2009. Biotechnol J. 4: 1586-95. PMID: 19918785
- 7,3',4'-Trihydroxyisoflavone inhibits epidermal growth factor-induced proliferation and transformation of JB6 P+ mouse epidermal cells by suppressing cyclin-dependent kinases and phosphatidylinositol 3-kinase. | Lee, DE., et al. 2010. J Biol Chem. 285: 21458-66. PMID: 20444693
- 7,3',4'-Trihydroxyisoflavone, a metabolite of the soy isoflavone daidzein, suppresses ultraviolet B-induced skin cancer by targeting Cot and MKK4. | Lee, DE., et al. 2011. J Biol Chem. 286: 14246-56. PMID: 21378167
- 7,3',4'-Trihydroxyisoflavone modulates multidrug resistance transporters and induces apoptosis via production of reactive oxygen species. | Lo, YL., et al. 2012. Toxicology. 302: 221-32. PMID: 22914566
- Inhibitory effects of isoflavonoids on rat prostate testosterone 5α-reductase. | Bae, M., et al. 2012. J Acupunct Meridian Stud. 5: 319-22. PMID: 23265084
- Transcriptomic study for screening genes involved in the oxidative bioconversions of Streptomyces avermitilis. | Kim, HJ., et al. 2013. Bioprocess Biosyst Eng. 36: 1621-30. PMID: 23474968
- Pharmacological chaperones increase residual β-galactocerebrosidase activity in fibroblasts from Krabbe patients. | Berardi, AS., et al. 2014. Mol Genet Metab. 112: 294-301. PMID: 24913062
- Design of acid-responsive polymeric nanoparticles for 7,3',4'-trihydroxyisoflavone topical administration. | Huang, PH., et al. 2016. Int J Nanomedicine. 11: 1615-27. PMID: 27143883
- Preparation, characterizations and anti-pollutant activity of 7,3',4'-trihydroxyisoflavone nanoparticles in particulate matter-induced HaCaT keratinocytes. | Huang, PH., et al. 2018. Int J Nanomedicine. 13: 3279-3293. PMID: 29910615
- Topical Application of 7,3',4'-Trihydroxyisoflavone Alleviates Atopic Dermatitis-Like Symptoms in NC/Nga Mice. | Park, SH., et al. 2020. Planta Med. 86: 190-197. PMID: 31853913
- Memory-enhancing effects of 7,3',4'-trihydroxyisoflavone by regulation of cholinergic function and BDNF signaling pathway in mice. | Kim, SK., et al. 2020. Food Chem Toxicol. 137: 111160. PMID: 31991199
- A novel mineralocorticoid receptor antagonist, 7,3',4'-trihydroxyisoflavone improves skin barrier function impaired by endogenous or exogenous glucocorticoids. | Lee, H., et al. 2021. Sci Rep. 11: 11920. PMID: 34099793
- Bitter Taste Receptors and Endocrine Disruptors: Cellular and Molecular Insights from an In Vitro Model of Human Granulosa Cells. | Luongo, FP., et al. 2022. Int J Mol Sci. 23: PMID: 36555195
Inhibitor of:
Cdk, Cot, MEK-4, MIF, and PI 3-kinase.Substrate of:
beta-Galactosidase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
3′,4′,7-Trihydroxyisoflavone, 200 mg | sc-206722 | 200 mg | $295.00 |