MIA2 Inhibitors
MIA2 inhibitors constitute a chemical class that aims to modulate the activity or function of the MIA2 protein. Recognizing that direct inhibitors for MIA2 aren't established, these chemicals have been chosen based on their to indirectly influence pathways and processes related to MIA2's function.
Compounds like Brefeldin A, Golgicide A, and Monensin focus on the Golgi apparatus and the protein transport mechanisms, targeting the secretory pathway which MIA2 is involved in. SecinH3, by inhibiting cytohesins, presents an avenue to alter protein secretion, while Exo1 disruption of the exocyst complex impacts vesicular trafficking. H89's inhibition of PKA and Wortmannin's interference with PI3K cascade both represent broader impacts on cellular processes, including secretion. Thapsigargin and Tunicamycin bring about disturbances in the ER by affecting calcium homeostasis and glycosylation respectively, processes integral to protein secretion. Eeyarestatin I provides an approach to influence protein secretion and degradation by targeting ERAD. The transportation of vesicles, central to secretion, is targeted by Nocodazole and Dynasore, which affect microtubules and endocytosis respectively.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Disrupts the Golgi apparatus and protein transport from the ER to the Golgi. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $152.00 $515.00 | ||
Ionophore affecting intracellular protein transport and secretion. | ||||||
Golgicide A | 1005036-73-6 | sc-215103 sc-215103A | 5 mg 25 mg | $187.00 $670.00 | 11 | |
Specifically targets and disrupts the Golgi apparatus. | ||||||
SecinH3 | 853625-60-2 | sc-203260 | 5 mg | $273.00 | 6 | |
Alters protein secretion by inhibiting cytohesins. | ||||||
Exo1 | 461681-88-9 | sc-200752 sc-200752A | 10 mg 50 mg | $82.00 $291.00 | 4 | |
Disrupts the exocyst complex, affecting vesicular trafficking. | ||||||
H-89 dihydrochloride | 130964-39-5 | sc-3537 sc-3537A | 1 mg 10 mg | $92.00 $182.00 | 71 | |
Protein kinase A (PKA) inhibitor which can affect various cellular processes including secretion. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
PI3K inhibitor that can interfere with multiple intracellular pathways. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
ER calcium ATPase inhibitor, affecting calcium homeostasis and protein secretion. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $169.00 $299.00 | 66 | |
Inhibits N-linked glycosylation in the ER, affecting protein folding and secretion. | ||||||
Eeyarestatin I | 412960-54-4 | sc-358130B sc-358130 sc-358130A sc-358130C sc-358130D sc-358130E | 5 mg 10 mg 25 mg 50 mg 100 mg 500 mg | $112.00 $199.00 $347.00 $683.00 $1336.00 $5722.00 | 12 | |
ER-associated degradation (ERAD) inhibitor, affects protein secretion and degradation. | ||||||