MHC class IIβ Inhibitors
MHC class IIβ inhibitors, as described above, comprise a diverse set of chemicals that predominantly function by influencing the pathways and cellular processes surrounding MHC class II antigen presentation rather than directly targeting the protein itself. These chemicals often interfere with the intricate cellular machinery involved in processing and presenting antigens, leading to reduced or altered MHC class II activity.
For instance, Chloroquine and Leupeptin can obstruct antigen processing by manipulating endosomal acidification and protein degradation respectively. Brefeldin A and Monensin, on the other hand, act on the transport mechanisms of the cell, limiting the presence of MHC class II on the cell surface, hence affecting antigen presentation. Some of these chemicals, such as Cyclosporine A and Rapamycin, are known for their profound effects on T cell activation and proliferation, providing indirect influence on MHC class II mediated immune responses. Other inhibitors, like MG-132 and Epoxomicin, specifically target proteasomes, essential components in the antigen-processing pathway.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Leupeptin hemisulfate | 103476-89-7 | sc-295358 sc-295358A sc-295358D sc-295358E sc-295358B sc-295358C | 5 mg 25 mg 50 mg 100 mg 500 mg 10 mg | $73.00 $148.00 $316.00 $499.00 $1427.00 $101.00 | 19 | |
Protease inhibitor that prevents the degradation of internalized proteins, affecting antigen processing. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Disrupts protein transport from the endoplasmic reticulum to the Golgi, inhibiting MHC class II expression on the cell surface. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $63.00 $92.00 $250.00 $485.00 $1035.00 $2141.00 | 69 | |
Immunosuppressant that can inhibit T cell activation, indirectly affecting MHC class II mediated immune responses. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Inhibits mTOR pathway, leading to reduced T cell proliferation and affecting MHC class II presentation downstream. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
Proteasome inhibitor which can interfere with protein degradation necessary for antigen presentation. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $155.00 $525.00 | ||
Disrupts Golgi function, leading to reduced transport of MHC class II molecules to the cell surface. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $70.00 $215.00 | 26 | |
Glycolysis inhibitor that can reduce cellular energy, potentially impacting antigen processing and presentation. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
PI3K inhibitor which can interfere with various cellular processes, including those related to MHC class II. | ||||||
Calpeptin | 117591-20-5 | sc-202516 sc-202516A | 10 mg 50 mg | $121.00 $456.00 | 28 | |
Calpain inhibitor that can impact cellular protein degradation pathways associated with MHC class II. | ||||||
Epoxomicin | 134381-21-8 | sc-201298C sc-201298 sc-201298A sc-201298B | 50 µg 100 µg 250 µg 500 µg | $137.00 $219.00 $449.00 $506.00 | 19 | |
Specific proteasome inhibitor that affects protein degradation and subsequent MHC class II antigen presentation. | ||||||