MFSD8 Activators
MFSD8 activators belong to a category of chemical agents that interact with the Major Facilitator Superfamily Domain containing 8 (MFSD8) protein. MFSD8, a member of the larger Major Facilitator Superfamily (MFS), is a transmembrane protein that typically functions in transport processes across cellular membranes. The MFS proteins are characterized by their ability to facilitate the movement of a variety of substrates across cell membranes, including ions, sugars, amino acids, and other small molecules, utilizing diverse mechanisms such as uniport, symport, or antiport. MFSD8 activators, therefore, are chemicals designed to modulate the activity of the MFSD8 protein, influencing its natural role in the transport mechanisms within the cells.
The interaction between MFSD8 activators and the MFSD8 protein can modulate its function at a molecular level. These activators may bind to specific sites on the MFSD8 protein, inducing conformational changes that can enhance its transport activity. Since the MFSD8 protein is embedded in the cellular membrane, activators often possess certain physicochemical properties that enable them to traverse the hydrophobic lipid bilayer to reach their target. This interaction is highly specific, as the chemical structure of an activator determines its affinity and efficacy in modulating the MFSD8 protein function. The structure-activity relationship (SAR) is a critical aspect in the development and understanding of MFSD8 activators, providing insights into how different chemical modifications can impact the interaction with the protein and its subsequent activation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $62.00 $90.00 $299.00 $475.00 $1015.00 $2099.00 | 69 | |
Cyclosporin A binds to the cyclophilins which inhibits the phosphatase activity of calcineurin, thereby influencing intracellular signaling pathways that could enhance the lysosomal function, potentially increasing the activity of MFSD8 which is localized in lysosomes. | ||||||
Methyl-β-cyclodextrin | 128446-36-6 | sc-215379A sc-215379 sc-215379C sc-215379B | 100 mg 1 g 10 g 5 g | $25.00 $65.00 $170.00 $110.00 | 19 | |
Methyl-β-cyclodextrin extracts cholesterol from cell membranes, which may alter the composition and function of lysosomal membranes, potentially enhancing the activity of lysosome-associated proteins like MFSD8. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, which is a key regulator of autophagy. Inducing autophagy could enhance the degradation processes within lysosomes, where MFSD8 is active. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine raises the pH of lysosomes, which could modulate the catabolic activity within the organelle. An altered lysosomal environment may indirectly enhance the function of MFSD8 by affecting substrate availability. | ||||||
E-64 | 66701-25-5 | sc-201276 sc-201276A sc-201276B | 5 mg 25 mg 250 mg | $275.00 $928.00 $1543.00 | 14 | |
E-64d is an irreversible cysteine protease inhibitor that can lead to the accumulation of certain substrates within lysosomes, potentially enhancing the functional activity of lysosomal proteins including MFSD8. | ||||||
Z-VAD-FMK | 187389-52-2 | sc-3067 | 500 µg | $74.00 | 256 | |
Z-VAD-FMK is a pan-caspase inhibitor that can prevent apoptosis. By maintaining cell viability, it indirectly supports the continued activity of cellular proteins, including MFSD8. | ||||||
Leupeptin hemisulfate | 103476-89-7 | sc-295358 sc-295358A sc-295358D sc-295358E sc-295358B sc-295358C | 5 mg 25 mg 50 mg 100 mg 500 mg 10 mg | $72.00 $145.00 $265.00 $489.00 $1399.00 $99.00 | 19 | |
Leupeptin inhibits lysosomal proteases like cathepsins. This inhibition could increase the activity of MFSD8 by reducing the degradation of its potential substrates within lysosomes. | ||||||
Nystatin | 1400-61-9 | sc-212431 sc-212431A sc-212431B sc-212431C | 5 MU 25 MU 250 MU 5000 MU | $50.00 $126.00 $246.00 $3500.00 | 7 | |
Nystatin binds to ergosterol and alters membrane permeability, which can influence lysosomal membrane integrity and potentially enhance the activity of lysosomal proteins such as MFSD8. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin has been shown to induce autophagy through multiple pathways. Enhanced autophagy may indirectly lead to increased lysosomal activity and thus potentially increase the functional activity of MFSD8. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $43.00 $65.00 $200.00 $815.00 | 6 | |
Nicotinamide is a precursor of NAD+ and is involved in sirtuin signaling. Sirtuins can influence lysosomal function, which may indirectly enhance the activity of lysosomal proteins like MFSD8. | ||||||