METTL12 Inhibitors
METTL12 inhibitors represent a category of compounds that target and inhibit the activity of the methyltransferase-like 12 (METTL12) enzyme, which is part of the broader family of methyltransferases. Methyltransferases catalyze the transfer of methyl groups to various biomolecules, including proteins, nucleic acids, and small molecules, thus playing a crucial role in regulating biological processes such as gene expression, RNA stability, and protein function. METTL12, like other members of the methyltransferase family, likely influences cellular pathways by modifying specific substrates through methylation, although its precise biochemical targets and broader role within cellular contexts remain a subject of investigation. Inhibitors of METTL12 are of interest for their ability to interfere with these methylation processes, offering a route to study the enzyme's functional role in different systems and its impact on the regulation of cellular pathways. These inhibitors typically bind to the enzyme's active site or key regulatory regions, preventing the transfer of methyl groups to substrates.
Structurally, METTL12 inhibitors are designed to exploit the unique active site topology of the METTL12 enzyme, which differs in subtle ways from other methyltransferases, allowing for selective binding. Such selectivity is critical in avoiding cross-reactivity with other methyltransferases, as inhibition of these enzymes could lead to unintended modulation of unrelated cellular pathways. The design of METTL12 inhibitors often involves identifying small molecules that can either mimic the enzyme's natural substrates or act as competitive inhibitors, blocking substrate access to the catalytic site. Through structural biology techniques such as X-ray crystallography or NMR, researchers can analyze the enzyme-inhibitor complexes to refine the molecular features required for effective binding. By studying METTL12 inhibitors, researchers can further elucidate the specific biochemical processes governed by METTL12 and how methylation, in general, influences the regulation of molecular interactions in the cell.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Homocysteine | 6027-13-0 | sc-507315 | 250 mg | $195.00 | ||
S-(5'-Adenosyl)-L-homocysteine is a product inhibitor of methyltransferase reactions, which would inhibit Methyltransferase-like protein 12 by competing with the methyl donor S-Adenosyl-L-methionine, reducing methyl group transfer activity. | ||||||
5′-Deoxy-5′-methylthioadenosine | 2457-80-9 | sc-202427 | 50 mg | $120.00 | 1 | |
5′-Deoxy-5′-methylthioadenosine acts as a methylthioadenosine phosphorylase inhibitor. By inhibiting this enzyme, the salvage pathway for S-Adenosyl-L-methionine is impaired, potentially leading to reduced substrate availability for Methyltransferase-like protein 12. | ||||||
BIX01294 hydrochloride | 1392399-03-9 | sc-293525 sc-293525A sc-293525B | 1 mg 5 mg 25 mg | $36.00 $110.00 $400.00 | ||
BIX01294 is a histone methyltransferase inhibitor that targets G9a and GLP methyltransferases. It can inhibit Methyltransferase-like protein 12 by interfering with similar active sites or catalytic processes involved in the transfer of methyl groups to substrates. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $128.00 $505.00 | 2 | |
RG 108 is a non-nucleoside DNA methyltransferase inhibitor that might inhibit Methyltransferase-like protein 12 by blocking the active site of the enzyme, thus preventing the methylation process. | ||||||
Chaetocin | 28097-03-2 | sc-200893 | 200 µg | $120.00 | 5 | |
Chaetocin is a known inhibitor of histone methyltransferases, particularly SUV39H1. It inhibits methyltransferases through competitive inhibition with the cofactor S-Adenosyl-L-methionine, and could inhibit Methyltransferase-like protein 12 in a similar fashion. | ||||||
Epz004777 | 1338466-77-5 | sc-507560 | 100 mg | $575.00 | ||
EPZ004777 is a selective inhibitor of DOT1L, a histone H3 lysine 79 methyltransferase. It inhibits methyltransferases by mimicking the substrate and could potentially inhibit Methyltransferase-like protein 12 by occupying its substrate binding site. | ||||||
3-Deazaneplanocin, HCl salt | 120964-45-6 | sc-351856 sc-351856A sc-351856B | 1 mg 5 mg 10 mg | $251.00 $600.00 $918.00 | 2 | |
3-Deazaneplanocin, or 3-Deazaneplanocin hydrochloride, is an S-Adenosylhomocysteine hydrolase inhibitor that leads to increased levels of S-(5'-Adenosyl)-L-homocysteine, a strong methyltransferase inhibitor, thereby inhibiting Methyltransferase-like protein 12 by increasing levels of its endogenous inhibitor. | ||||||
AMI-1, sodium salt | 20324-87-2 | sc-205928 sc-205928A | 5 mg 25 mg | $112.00 $390.00 | 2 | |
AMI-1 is a compound that inhibits arginine methyltransferases and could inhibit Methyltransferase-like protein 12 by altering its ability to methylate arginine residues on its substrate proteins. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
5-Aza-2′-Deoxycytidine is a cytidine analog that inhibits DNA methyltransferases. It is incorporated into DNA where it can inhibit Methyltransferase-like protein 12 by trapping it in a covalent complex with DNA, thus preventing enzyme turnover. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine, a nucleoside analog of cytidine, can be incorporated into RNA and DNA and inhibit DNA methyltransferases, potentially inhibiting Methyltransferase-like protein 12 by forming a covalent complex with the enzyme. | ||||||